建立心脏功能研究的计算机模型-湖南师范大学.PDF

6 4 ( ) 生命科学研究 Vol. 6 No.4(Suppl.) 200212 Life Science Research Dec. 2002 X 齐兴柱, 袁婺洲, 吴秀山 ( , 410081) : 用计算机模拟建立生物学模型在现代生物学研究中是一 非常重要的方法.就心脏而言, 从基因到细 胞到整 个器官, 现在都建立了大量的计算机模型.这些模型在帮助我们证实心脏功能机制的假说预测和评估 药物的作用以及诊断疾病等方面都起着重要作用. 就心脏不同层面的计算机模型进行了简要的综述. : 基因组; 心脏细胞模型; 药物评估 : 811.2 :A : 1007-7847(2002) S1-0110-04 Establishing Models by Computer to Analysis Functions of the Heart I Xing-zhu, YUAN Wu-zhou, WU Xiu-shan ( College of Lfi e Sciences,H unan Normal Univ ersity , Chang sha 410081,H unan , China) Abstract: Establishing biological model by computer is an important method in the research work of modern biolo- gy. Thehuge amount of computer models from genes to cellstothewholeorgan in the caseof heart havebeen estab- lished. Those models can help us to verify hypotheses about functional mechanisms of the heart, to assess and to predict drug actions, and to diagnose diseases etc.The heartcs models by computer from molecular to organ were summarized. Key words: genomics;cardiac cell model;assessing drug actions (Lfi e Science Research ,2002,6(Suppl) : 110~ 113) , . , . . ,, ., 3 ., , , ,