Diels_Alder环加成点击反应_熊兴泉.pdf

DOI: 10.6023/cjoc201212016 综述与进展 有机化学 Chinese Journal of Organic Chemistry REVIEW Diels-Alder 环加成点击反应 熊兴泉* 陈会新 (华侨大学材料科学与工程学院 福建省高校功能材料重点实验室 厦门 361021) 摘要 点击反应由于其高效、高选择性以及可靠等特点迅速成为药物、聚合物以及功能材料等合成的新方法. 随着对 点击反应研究的深入, 其反应类型在不断增多, 应用范围也在不断扩大. Diels-Alder (D-A)反应作为一种重要的点击反 应, 不仅具有简便高效、原料易得以及反应条件温和等优点, 而且克服了叠氮/炔间 Cu(I)催化的 Cue-AAC 反应引起的 金属污染等缺点, 为功能性材料的制备提供更可行的途径. 从 D-A 反应的概念、特征和类型出发, 重点介绍了它在合 成制备树状分子、功能性聚合物以及表面修饰等方面的应用, 并展望了它的发展前景. 关键词 点击化学; D-A 反应; 功能性聚合物; 表面修饰; 应用 Diels-Alder Cycloaddition Click Chemistry Xiong, Xingquan* Chen, Huixin (Key Laboratory for Functional Materials of Fujian Higher Education, College of Materials Science and Engineering, Huaqiao University, Xiamen 361021 ) Abstract Click reactions have rapidly become a new method for the synthesis of drugs, polymers and functional materials because of its high efficiency, high selectivity and reliable characteristics. With the further research of click reactions, the types of them are increasing continuously and the scope of application is also expanding at a fast rate. As an important reaction of click chemistry, Diels-Alder (D-A) reaction not only has high reaction efficiency, but also overcomes the shortcoming of using toxic heavy metal in the copper(I) catalyzed Cue-AAC reaction, so it provides a possible synthetic method for functional ma- terials. Basin