第七单元：肝癌预后危险因素.doc

clinicopathological factors Age ≤65 65 Sex M F Presentation Subclinical Symptomatic Hepatitis B surface antigen Positive Negative Hepatitis C antibody Positive Negative Dual infection Positive Negative Child classification Grade A Grade B Preoperative ICG R-15 min (%) ≤15 15 Serum Urea nitrogen (mg/dl) ≤21 21 Serum Creatinine (mg/dl) ≤1.4 1.4 Serum Albumin (g/dl) ≤3.5 3.5 Serum Alkaline phosphatase (U/L) ≤94 94 Serum Aspartate aminotransferase (U/L) ≤34 34 Serum Alanine aminotransferase (U/L) ≤36 36 Serum Total bilirubin (mg/dl) ≤2.0 2.0 Platelet count (≤109/L) ≤150 150 Prothrombin time/prolong (s) ≤4.0 4.0 Extent of resection（Type of resection） Major hepatectomy Minor hepatectomy Major resection is defined as resection of ≥ three segments, minor resection as resection of ≤ two segments. Blood loss (L) ≤4 4 Blood transfusion No Yes Morbidity No Yes AFP ≤20 20 Rupture No Yes Tumor size (cm) ≤2？5？ 2？5？ Satellite lesions None Yes Resection margin (cm) ≤1 1 Capsular formation Positive Negative Capsular invasion No Yes Vascular invasion No Yes Diploidy status Yes No Tumor number Solitary Multiple Macroscopic resection margin ≤1 cm ＞1 cm Microscopic resection margin Positive Negative Microscopic venous invasion No Yes Tumor encapsulation No Yes pTNM stage≈ I II IIIA IVA Abbreviation: pTNM stage, pathologic tumor-node-metastasis stage. 1 对于乙肝患者而言，术前HBV-DNA水平的影响很重要！ 此外，肝硬化、肝纤维化程度的影响！ The following clinicopathologic variables that might correlate with disease-free survival and recurrence rates were evaluated: 2 presence of HBsAg marker, presence of anti-HCV antibodies, Child classification, [alpha]-fetoprotein level, diameter of nodules (5 cm vs. 5 cm), number of nodules (single vs. multiple), preoperative intra-arterial chemoembolization, type of resection, intraoperative blood transfusion, micro- or macroscopic portal vein infiltration, presence of tumor capsule, preoperative aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels HBsAg pos