Lck和Fyn对T细胞发育过程的影响.pdfVIP

HEREDITAS (Beijing) 2012 3 , 34(3): 289―295 ISSN 0253-9772 综 述 DOI: 10.3724/SP.J.1005.2012.00289 Lck 和Fyn 对T 细胞发育过程的影响 1 1,2 1 戴鹏 , 刘欣 , 李庆伟 1. , 116029; 2. , 116029 胸腺中 T 细胞的发育及次级淋巴组织中成熟 T 细胞的活化均需要细胞能够对环境信号分子做出适应性 的反应。在共刺激分子及细胞因子受体介导的信号参与下通过TCR(T cell receptor )及其辅助受体CD4 和CD8 与MHC/抗原肽复合物相互作用, 可以诱导TCR 信号通路激活并最终导致T 细胞免疫反应的发生。Src 家族激 酶Lck(Lymphocyte-specific protein tyrosine kinase)和Fyn (Proto-oncogene tyrosine-protein kinase) 的激活是启动 TCR 信号通路的关键因素。在 T 细胞的发育、阳性选择、初始T 细胞的外周存活及由淋巴细胞缺失诱导的细 胞增殖中都起着关键性的作用。研究显示, 虽然这两种信号分子紧密相关, 但在某些条件下 Lck 发挥着比 Fyn 更重要的作用, 并且Fyn 仅可以补充Lck 的部分功能。文章针对这两个激酶在T 细胞发育的整个过程中的作用 机制进行了论述。 Lck; Fyn; TCR; 细胞发育; 信号转导 Function of the Lck and Fyn in T cell development 1 1, 2 1 DAI Peng , LIU Xin , LI Qing-Wei 1. Institute of Marine Genomics Proteomics, Liaoning Normal University, Dalian 116029, China; 2. College of Urban and Environmental Science, Liaoning Normal University , Dalian 116029, China Abstract: The development of T cell in the thymus and the activation of mature T cells in the secondary lymphoid tis- sues require T cell to make adaptive responses to signaling molecules of environment. The activation of T cell receptor (TCR) signaling pathway could be induced by the interaction of the TCR and its co-receptor CD4 and CD8 with MHC/peptide complex. This process involves co-stimulatory molecules and signals mediated by cytokine receptors, which eventually leads to the occurrence of T cell immune response. The Src-family kinases lymphocyte-specific protein tyrosine kinase (Lck) and proto-oncogene tyrosine-protein kinase (Fyn) are expressed in T cells and serve as the