Pax6基因突变与胰腺发育和糖尿病发生关系的研究进展.pdfVIP

上海交通大学学报(医学版) V01．31No．5 2011 Journalof University(MedicalScience) May ShanghaiJiaotong [文章编号】 1674-8115(2011)05—0663—04 ·综 述· Pax6基因突变与胰腺发育和糖尿病发生关系的研究进展 陆玉凤1’2，刘丽梅1 (上海交通大学附属第六人民医院内分泌代谢科上海市糖尿病研究所，上海200233；2．苏州大学，苏州215006) 活、p细胞功能以及胰岛素表达密切相关的关键转录因子，在众多调节p细胞发育的基因中发挥中心作用，其突变／变异已成为 糖耐量异常和早发糖尿病的致病原因或易感位点。该文就Pax6基因突变与胰腺发育及糖尿病发病关系的研究进展进行综述。 [关键词]配对盒因子6基因；突变；胰腺发育；糖尿病 [中图分类号]R587．1 【文献标志码】A [DOI]10．3969／j．issn．1674—8115．2011．05．029 Research ofPax6 mutationand of and progress gene developmentpancreas mellitus diabetes LU Li—meil Yu—fen91一．LIU Diabetes and Sixth Metabolism，the (ShanghaiInstitute，DepartmentofEndocrinology PeoplesHospital，ShanghaiJiaotong 200233，China；2．Suzhou Unive邝ity，Shanghai University,Suzhou215006，China) box oneofthe factor an 【Abstract】Paired membersofPax 6(Pax6)is polygenetranscriptionfamily，andplaysimportant roleinthe of andactivationof cellfunctionand developmentpancreas，仅celldifferentiation，transcriptionglucagongene，B ofinsulin．Pax6isthe in the of itsmutationcontributestothe major cells，and expression generegulatingdevelopmentB of toleranceand diabetesmellitus．Theresearch ofassociationsofPax6 pathogenesisimpairedglucose early—onset progress mutationwith of anddiabetesmellitusisreviewedinthis developmentpancreas paper． box6 mellitus 【Keywords】pairedgene；mutation；pancreatic