pdx1基因及其表观遗传修饰对胰腺发育及β细胞功能的影响.pdfVIP

·综述- pdxl基因及其表观遗传修饰对胰腺发育及p细胞 功能的影响 侯若琳(综述) 王秀敏赵正言(审校) 【摘要】 胚胎时期的发育状况与成年人2型糖尿病的发生密切相关。胰十二指肠同源盒(pancreatic andduodenalhomeobox 1，PDXl)表达于B细胞发育的所有阶段和成熟的13细胞中，是对整个胰腺形成特别 是胎儿期13细胞发育和功能起主要作用的转录因子，同时也是维持成熟B细胞功能所必需的；而pdxl表 观遗传修饰的改变会影响其表达，进而影响胰腺发育和13细胞功能。 【关键词】2型糖尿病；表观遗传修饰；胰腺发育相关基因pdxl； Influenceof andits modification and function upon pdxlgene epigenetic pancreaticdevelopmentpcell HOU Child Children’S Ruo-lin，WANGXiu—rain，ZHAOZheng—yah．Departmentof Health，AffiliatedHospital， School 310003。China ZhejiangUniversityofMedicine，Hangzhou of hascloserelationwiththeoccurrenceof 2diabetesin 【Abstract】Thedevelopmentembryo type adulthoodandis moreattention andduodenalhomeobox attractingincreasingly recently．Pant·reatic 1(pdxl) inall of andinmaturecells．Asa acritical expressesstages13-celldevelopment B transcriptionfactor，pdxlplays role the whole inthe andfunctionof infetal it in formationof pancreas，especiallydevelopment B—cell period，and in modification isalso forthemaintenanceofmature can necessary 13-cellfunction．However，changesepigenetic function．We alterthe of theninfluence and willmakea expressionpdxl，and pancreaticdevelopment13-cell aboutI modificationandSOon． summary pdxgenestructure，function，regulation，epigenetic 2 associatedwith 【Keywords】Typediabetes；Epigeneticmodification；pdxlgene pancreatic development 胚胎期胎儿的发育在糖尿病发病机制中发挥重要 守…。人类pd