PI3K信号通路对T细胞发育、活化、增殖、分化及支气管哮喘的作用.pdfVIP

PI3K信号通路对T细胞发育、活化、增殖、 分化及支气管哮喘的作用 聂颖 李昌崇 [摘要]T细胞是参与支气管哮喘发病的重要效应细胞，而磷脂酰肌醇-3-激酶(PI3K)是T细胞的 重要信号转导分子。PI3K信号通过影响双阴性细胞的β-选择而影响T细胞的成熟，还通过激活PKB、 Rac等信号途径而参与T细胞的活化、分化。同时，PI3K通过参与Th1/Th2失衡的调节，嗜酸粒细胞、 肥大细胞的黏附、脱颗粒等而参与支气管哮喘气道炎症反应。 PI3K信号；T细胞；发育；分化；哮喘 Role of PI3K signal in development, activation, differentiation of T cell and bronchial asthma NIE Ying LI Chang-chong Department of Respiratory Diseases, Yuying Childrens Hospital Affiliated to Wenzhou Medical College ,Wenzhou 325027 ,China [Abstract] T lymphocyte is the core cell in the bronchial asthma. The phosphoinositide3-kinase (PI3K) pathway is the important signal transduction pathway in the T lymphocyte. PI3K signaling plays a role in the development of T cells through affecting the double-negative cells of the β-selection, and T cell activation and differentiation through activation of PKB, Rac and other signaling pathway. At the same time, PI3K signal also involved in the airway inflammation of asthma including the regulation of Th1/Th2 imbalance, adhesion, degranulation of eosinophils and mast cells. Phosphoinositide3-kinase signal; T cell; Development; Differentiation; Asthma 10. 3760/cma. j.issn. 1673-436X. 2011. 019. 007 基金项目:浙江省自然基金资助项目(Y2090327);浙江省大学生 科技创新活动计划（新苗人才计划）资助项目(2010R413044) 325027 温州医学院附属育英儿童医院呼吸科 ·1467· ·1468· @@[1] Deane JA, Fruman DA. Phosphoinositide 3-kinase: diverse roles in immune cell activation. Annu Rev Immunol, 2004,22: 563-598. @@[2] Isakoff SJ, Cardozo T, Andreev J, et al. Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast. EMBO J , 1998,17 : 5374-5387. @@[3] Geering B, Cutillas PR, Vanhaesebroeck B. Regulation of class IA PI3Ks:is there a role for monomeric PI3K subunits? Biochem Soc Trans,2007,35(Pt 2) :