第2讲 第四节 剂型因素.pdf

第四节剂型因素对药物吸收的 本节主要内容 影响 固体制剂的崩解与溶出 剂型对药物吸收的影响 教师 张青 处方对药物吸收的影响 工艺对药物吸收的影响 This test is provided to determine 4.1固体制剂的崩解与溶出 whether tablets or capsules disintegrate within the prescribed time when placed (1)、崩解 in a liquid medium at the experimental 崩解的意义：固体制剂在检查时限内崩 conditions presented below. Compliance 解或者溶散成碎粒的过程。（除不溶性 with the limits on Disintegration stated in the individual monographs is required 包衣材料和胶囊壳） except where the label states that the 美国药典中的定义： tablets or capsules are intended for use as troches,or are to be chewed, or are designed as extended-release dosage form or delayed-release dosage forms. 装置：升降式崩解仪 标准 普通片 15min内崩解 薄膜衣片 稀盐酸中30min崩解 糖衣片 稀盐酸中 1hr崩解 肠溶衣片 前2hr 稀盐酸中不得崩解 后1hr pH6.8PBS中崩解 1 -测定方法 溶出度测定有转篮法、桨法、循环法及崩解仪法等。