英文版血栓性微血管病必威体育精装版诊疗进展.pdf

T h e n e w e ngl a nd j o u r na l o f m e dic i n e review article Dan L. Longo, M.D., Editor Syndromes of Thrombotic Microangiopathy James N. George, M.D., and Carla M. Nester, M.D. From the Department of Biostatistics he thrombotic microangiopathy (TMA) syndromes are extraor­ and Epidemiology, College of Public dinarily diverse. They may be hereditary or acquired. They occur in children Health, and the Department of Internal Tand adults. The onset can be sudden or gradual. Despite their diversity, TMA Medicine, College of Medicine, University of Oklahoma Health Sciences Center, syndromes are united by common, defining clinical and pathological features. The Oklahoma City (J.N.G.); and the Stead clinical features include microangiopathic hemolytic anemia, thrombocytopenia, Family Department of Pediatrics and De- 1 partment of Internal Medicine, University and organ injury. The pathological features are vascular damage that is manifested of Iowa, Iowa City (C.M.N.). Address re- by arteriolar and capillary thrombosis with characteristic abnormalities in the en- print requests to Dr. George at the De- 2 dothelium and vessel wall. We focus on nine disorders that we describe as pri- partments of Internal Medicine and Bio- statistics and Epidemiology, University of mary TMA syndromes, for which there is evidence supporting a defined abnormal- Oklahoma Health Sciences Center, P.O. ity as the probable cause (Table 1 a