Int J Mol Med (髓鞘 年度龄).pdf

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 32: 1021-1028, 2013 Age-related decline of myelin proteins is highly correlated with activation of astrocytes and microglia in the rat CNS FANG XIE1,2*, JIU-CONG ZHANG3* , HAN FU1* and JUN CHEN 1 1 Institute for Biomedical Sciences of Pain, Tangdu Hospital, The Fourth Military Medical University, 2 Xian, Shaanxi 710038; Department of Stress Medicine, Institute of Basic Medical Sciences, 3 Academy of Military Medicine Sciences, Beijing 100850; Department of Gastroenterology, Lanzhou General Hospital of Lanzhou Military Command, Lanzhou, Gansu 730050, P.R. China Received May 18, 2013; Accepted August 19, 2013 DOI: 10.3892/ijmm.2013.1486 Abstract. It has been shown that aging can greatly influence as an insulate cable-coat, in maintaining the fast saltatory the integrity and ultrastructure of white matter and the myelin conduction of action potentials along the nerve fibers (1). The sheath; however, studies regarding the effects of aging on the lipid-rich feature of the myelin sheath makes it very fragile expression of myelin proteins are still limited. In the present to the environmental changes in the brain, such as metabolic study, immunohistochemical mapping was used to investigate disorders and aging. Due to the sensitivity of myelin sheath to the overall expression of myelin basic protein (Mbp) and senescence, it is thought to be one of the major targets of brain myelin oligodendrocyte glycoprotein (Mog) in t