饮食营养及健康对结直肠癌的影响的统计分析.docx

南方医科大学高等教育自学考试毕业论文?题目：饮食营养与健康对结直肠癌的影响的统计分析?作者姓名：ⅹⅹⅹ?专业：ⅹⅹⅹⅹ?时间：ⅹⅹⅹⅹ年ⅹⅹ月饮食营养与健康对结直肠癌的影响的统计分析摘要目的：探讨饮食总能量、蛋白质、脂肪和碳水化合物摄取以及微量元素与结直肠癌发病风险的关系。方法：在广东省进行的一项病例对照研究，用包括 83 种食物摄取频度和摄取量的问卷表，调查了 122 例结直肠癌患者和 103 例健康对照的饮食状况，计算各类饮食营养素的平均每日摄取量，采用三分位法分析营养素摄取与结直肠癌发病风险的关系，OR 值计算采用非条件 Logistic 回归方法。结果：结直肠癌组脂肪摄取量显著高于对照组；总能量和蛋白质摄取量显著低于对照组；碳水化合物摄取量显著低于对照组；钠和锰的每日摄取量显著低于对照组；钙、镁和锌的每日摄取量显著低于对照组。 在调整一些社会经济因素、营养素以及各种微量元素摄取后，钠和锌的每日摄取量增加显著降低结直肠癌的发病风险，OR 值分别为 0.50（95%CI：0.42~0.71）和 0.35（95%CI：0.22~0.63），而磷的摄取量增加显著升高直肠癌的发病风险（OR=2.08，95%CI：1.06~4.12）。 在调整可能的混杂因素影响后，总能量和碳水化合物摄取量高显著降低结直肠癌的发病风险， 脂肪摄取量高显著增加结直肠癌的发病风险。在营养素互相调整后，增加碳水化合物的摄取可显著降低结、直肠癌的发病风险（结肠癌 OR=0.44，95%CI：0.29~0.72；直肠癌 OR=0.52，95%CI：0.46~0.75）。结论：饮食营养素摄取影响结直肠癌的发病风险，增加碳水化合物摄取可预防结直肠癌的发生。饮食微量元素摄取量影响结直肠癌的发病风险，增加钠和锌的摄取可预防结直肠癌的发生，而磷的过量摄取是直肠癌发病的危险因素。关键词: 结直肠肿瘤；饮食；营养素；病例对照研究；广东Statistical analysis of the effect of diet nutrition and health on colorectal cancer[Abstract] Objective: To investigate the relationship between the total energy, dietary protein, fat and carbohydrate intake of trace elements and the risk of colorectal cancer. Methods: a case-control study was carried out in Guangdong Province, including 83 kinds of food intake and intake frequency questionnaire survey of 342 cases of patients with colorectal cancer and 393 cases of healthy diet, calculate all kinds of dietary nutrients average daily intake, analysis of the relationship between nutrient intake and colorectal cancer risk by three percentile method, OR value calculated by non conditional Logistic regression method. Results: colon cancer group fatFat intake was significantly higher than the control group; rectal cancer group total energy and protein intake was significantly lower than the control group; and the amount of carbohydrate intake in rectal cancer group were significantly lower than the control group. And the daily intake of sodium and manganese in rectal cancer group was significantly lower than the control group; the patients daily intake of calcium, magnesium and