纳米药物递释系统的脑靶向研究进展_刘洋.pdf

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纳米药物递释系统的脑靶向研究进展_刘洋.pdf

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纳米药物递释系统的脑靶向研究进展_刘洋

1532 Acta Pharmaceutica Sinica 2013, 48 (10): 1532−1543 1* , (, 201203) : , : , , : ; ; ; : R943 : A : 0513-4870 (2013) 10-1532-12 Research advances in brain-targeted nanoscale drug delivery system * LIU Yang, JIANG Chen (Key Laboratory of Smart Drug Delivery (Ministry of Education), School of Pharmacy, Fudan University, Shanghai 201203, China) Abstract : The blood-brain barrier (BBB) exerts its central nervous system (CNS) protective function as it hinders the delivery of diagnostic and therapeutic agents to the brain. With the development of nanotechnology during the last thirty years, the nanocarriers for delivering drugs make it possible to transport drugs across the BBB. The brain-targeted drug delivery system usually consists of two parts: nanocarriers and brain-targeted strategies. In this review, several kinds of nanocarriers are introduced for brain-targeted drug delivery. We focus on several possible strategies for brain-targeting and comment on their advantages and disadvantages in application. Key words: drug targeting; nanomedicine; blood-brain barrier; brain disease  (blood brain barrier, BBB) , , [1] (brain capillary endothelial cells, BCECs)