某些药物代谢动力学数据备考复习.docx

某些药物代谢动力学数据药物生物利用度（%）尿排泄（%）血浆蛋白结合（%）清除率（ml·min-1·kg-1）分布容积（L/kg）半衰期（h）醋丁洛尔acebutolol3740266.81.22.7阿昔洛韦aciclovir15～3075153.370.692.4别嘌醇allopurinol80～9010112.70.6～1.61～3阿普洛尔alprenolol8.60.285153.32.5金刚烷胺amantadine50～9050～90674.86.616两性霉素B amphotericin B-2～5900.460.7618阿米卡星amikacin-9841.30.272.3胺碘酮amiodarone4601001.96625d阿米替林amitriptyline48294.811.51521.5氨苄西林ampicillin6282181.70.281.3阿斯匹林 aspirin681.4499.30.150.25阿替洛尔atenolol569452.40.956.1阿曲库铵atracurium-1-5.50.160.33阿托品 atropine505714～225.91.74.3硫唑嘌呤azathioprine602-570.810.16倍他米松betamethasone724.8642.91.45.6博莱霉素bleomycin-68-1.10.273.1布美他尼bumetanide8162992.60.130.8布比卡因bupivacaine-2957.10.92.4咖啡因 caffeine1001.1361.40.614.9卡托普利captopril653830120.812.2卡马西平carbamazepine701741.31.415羧苄西林carbenicillin-82500.680.181.0头孢克洛cefaclor-52256.10.360.67头孢氨苄cefalexin9091144.30.260.9头孢孟多cefamandole-96742.80.160.78头孢唑林cefazolin-80890.950.121.8头孢哌酮cefoperazone-2989～931.20.092.1头孢噻肟cefotaxime-50363.70.231.1头孢拉定cefradine9086145.10.250.77头孢曲松ceftriaxone-4690～950.240.167.3头孢呋辛cefuroxime-96330.940.191.7苯丁酸氮芥chlorambucil871992.60.291.3氯霉素chloramphenicol75～9025532.40.944.0氯喹chloroquine8961611.811541氯噻嗪chlorothiazide9～569294.64.50.201.5氯丙嗪 chlorpromazine32〈195～988．62130氯酞酮chlortalidone6465751.63.944西米替丁cimetidine6262198.31.02.0环丙沙星 ciprofloxacin6065406.01.84.1顺铂cisplatin-23-6.30.280.53氯贝特clofibrate955.796.50.120.1113氯硝西泮clonazepam981861.553.223可乐定clonidine9562203.12.112可卡因 cocain00.8可待因 codeine5007112.62.9环磷酰胺cyclophosphamide746.5131.30.787.5环孢霉素 cyclosporine231935.91.25.6氨苯砜dapsone9315730.61.022地塞米松dexamethasone782.6683.70.823.0地西泮 diazepam100198.70.381.143洋地黄毒甙digitoxin9032970.0550.546.7d地高辛digoxin7060250.88-39地尔硫?diltiaze13.7苯海拉明diphenhydramine721.9786.24.58.5丙吡胺disopyramide8355-1.20.596.0多巴酚丁胺dobutamine---590.22.4阿霉素doxorublicin51579西环素doxycycline9341880.530.7516依那普利enalapril4188504.91.711依诺沙星enoxacin79600--5红霉素 erythromycin3512849.10.781.6艾司洛尔esmolol-1551701.90.13乙胺丁醇ethambutol777958.61.63.1乙醇 ethanol803--0.54