养血清脑颗粒治疗紧张型头痛的临床观察_55756.doc

养血清脑颗粒治疗紧张型头痛的临床观察 北京医院王新德教授执笔 王新德1，匡培根2，罗胜1，贾建平3，杨志杰4，周宝玉5，余华峰6，常蜀英7，马维雅8 (1 北京医院神经科，北京100730；解放军301医院神经科；宣武医院神经科；北京大学第三临床医院神经科；中日友好医院神经科；同仁医院神经科；空军总医院神经科；武警总医院神经科) (摘要)目的 研究养血清脑颗粒（主要成分为当归、川芎、白芍、细辛等）治疗紧张型头痛的疗效及其不良反应。方法 112例紧张型头痛患者，年龄16—68岁，平均年龄为36.65±10.19， 进行了多中心、随机、双盲、安慰剂对照研究。结果 1、用药前后进行了治疗组和安慰组在不同时期发作次数（次）和持续时间（小时）的观察，发现10-天时发作次数在治疗组和安慰组分别为1.71±2.03和2.82±3.16，Z=2.02，P=0.04，持续时间分别为11.45±23.46和24.80±36.14,Z=3.57,P0.001 ,20-天时两组的发作次数分别为0.91±1.67和2.45±3.24, Z=2.35,P=0.02,持续时间分别为5.79±18.52和21.91±46.65,Z=3.12，P=0.002。2、治疗组中头痛消失时间随每次发作而明显缩短，而安慰剂组不明显(P0.01-0.03） 3、治疗组的显效率为30.9%,而安慰剂组仅5.6%（P0.001）。4、治疗组和安慰剂组的不良事件分别为3例（5.45%）和2例（3.64%）。 结论 养血清脑颗粒对紧张性头痛有较明显的疗效，可减少头痛的发作次数、发作持续时间和缩短头痛消失时间，是一种治疗紧张型头痛有效药物。 （关键词） 头痛，血管型；养血清脑颗粒，治疗应用 A clinical trial of Yangxueqingnaokeli in treatment of tension type headche.Wang Xinde,et al.Department of Neurology,Beijing Hospital,Beijing,100730 ,China [Abstract]Objects To investigate the therapeutic efficacy and side-effects of Yangxueqingnaokeli (its main composition is Chinese angelica,ligusticum wallichii,Paconia lactiflora,Asarum sieboldii,etc)in patients with tension headache. Methods One hundred and eleven patient with tension headache with an averge age of 36.65?10.19 years,ranging from 18-68 were investigated by menthod of multicenter,double-blind,randomized,controlled and perspective study. Results 1.The results of observation on number and duration(hours) of attack of headache at different periods in therapeutic and placebo group were shown as follows:at 10-days the number of attacks were1.71±2.03 and 2.82±3.16，respectively,Z=2.02，P=0.04，the duration of headeche was 11.45±23.46 and 24.80±36.14, respectively. Z=3.57,P0.001 ,At 20-days the number of attacks was 0.91±1.67and 2.45±3.24, respectively Z=2.35,P=0.02,duration of each attacks was 5.79±18.52and 31.91±46.66, respectively, Z=3.12，P0.01-0.03. 3.Remarkable efficacy rate in therapeutic and placebo group was 30.9% and 5.6%, respectively,Z=6.32 P0.001。4.The si