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葛根素对糖尿病大鼠肾组织中CXCL10·CXCR3表达影响的实验研究
Advances in Clinical Medicine 临床医学进展, 2017, 7(2), 66-71
Published Online June 2017 in Hans. /journal/acm
/10.12677/acm.2017.72011
Effects of Puerarin on the Expressions of
CXCR3/CXCL10 in Kidney of Diabetic Rats
*
Jingfang Liu , Qianqian Xiao, Sanyuan Wang, Han Li
The Department of Endocrinology, The First Hospital of Lanzhou University, Lanzhou Gansu
th th th
Received: May 17 , 2017; accepted: Jun. 11 , 2017; published: Jun. 14 , 2017
Abstract
Object: To observe the kidney pathological changes and the expressions of CXCR3/CXCL10 in kid-
ney of diabetic rats under the effect of Puerarin. Methods: Diabetes Mellitus (DM) model rats were
established by injecting streptozocin (STZ). Then the successful modeled rats were re-divided into
two groups: the DM group (n = 11) and the Puerarin group (n = 11). The normal group (n = 7) was
added too. The rats’ fasting plasma glucose levels and weight were detected every 2 weeks. The
excision of rats’ renal was finished 4 weeks later. The pathological changes in renal tissues were
examined by optical microscopy and electron microscope, and the expression levels of CXCL10/
CXCR3 were detected by RT-PCR. Results: Compared with the DM group, the renal injury, showed
by electron microscope, was lessened significantly; the expression of CXCR3, showed by the results
of RT-PCR, was reduced effectively in rats’ renal of the Puerarin group (p 0.05), but the decrease
of CXCL10 was not significant (p 0.05). Conclusion: One possible reason, for lessening injury of
DM rats’ renal by Puerarin, is that Puerarin relieves the inflammation by reducing the expression
level of CXCR3.
Keywords
Diabetes Mellitus, Renal Injury, Puerarin, CXCL10, CXCR3
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