体外评价29种中药的抗结核分枝杆菌活性.pdf

Hans Journal of Medicinal Chemistry 药物化学, 2017, 5(3), 39-44 Published Online August 2017 in Hans. /journal/hjmce /10.12677/hjmce.2017.53006 In Vitro Evaluation of the Potential Anti Mycoba-Cterium Tuberculosis Activity of 29 Chinese Traditional Medicinal Plants Lifen Han, Shanmin Song, Wei Deng, Menglan Gan, Renfeng Wang, Zaichang Yang* School of Pharmaceutical, Guizhou University, Guiyang Guizhou th th st Received: Jul. 11 , 2017; accepted: Jul. 29 , 2017; published: Aug. 1 , 2017 Abstract Tuberculosis is one of common infectious diseases that has been difficult to control so far and has been on the rise in recent years. Chinese herbal medicine is an important natural resource for the discovery of new drug, and China has a wealth of natural medicine resources. In this experiment, 29 traditional Chinese medicines were selected for the screening of anti-M tuberculosis H37Rv and BCG respectively. The results indicated that 14 kinds of herbs showed powerful activity against Mycobacterium tuberculosis H37Rv and BCG. Among them, 9 kinds of Chinese herbal medicine exhibited synergistic antibacterial effect combined with isoniazid and rifampicin re- spectively. In addition, it was first discovered that the Sanjiaotiao (Chinese name) had anti-Myco bacterium tuberculosis activity. The study laid the foundation for the discovery of the new skele- ton of anti-Mycobacterium tuberculosis drug. Keywords Mycobacterium Tuberculosis, Traditional Chinese Medicine, Bioassay Screening 体外评价29种中药的抗结核分枝杆菌活性 * 韩立芬，宋善敏，邓 伟，甘梦兰，王仁凤，杨再昌 贵州大学药学院，贵州 贵阳 收稿日期：2017年7月11 日；录用日期：2017年7月29 日；发布日期：2017年8月1 日 *通讯作者