动脉粥样硬化血栓形成的防治.ppt

拜阿司匹灵?肠道内缓慢释放，不损伤肠粘膜 《抗血小板药物消化道损伤和治疗中国专家共识》 规范抗血小板药物消化道损伤的处理 中华内科杂志2009;48(7):607 阿司匹林出血处理策略 阿司匹林导致的消化道出血在内镜下止血后治疗 停药组 阿司匹林联合PPI治疗 心脑血管事件 总死亡率 氯吡格雷替代治疗 溃疡复发及出血增加 阿司匹林最佳剂量－100mg Antithrombotic Trialists’ Collaboration. BMJ 2002;324:71-86 500-1500mg/d 160-325mg/d 75-150mg/d 75mg/d 0.0 0.5 1.0 1.5 2.0 19% 26% 32% 13% 阿司匹林剂量 风险降低值 小剂量阿司匹林(75-150mg/d)可以有效用于高危患者严重血管事件的长期预防 小剂量阿司匹林发挥最大效应 P0.0001 谢谢大家 * A recent analysis of the US data from the Framingham Heart Study evaluated the outcomes of patients in the study.1 This analysis was conducted to determine the impact of cardiovascular (and cerebrovascular) disease on life expectancy. The study used 40 years of data collected on 5,070 patients who did not have cardiovascular disease upon study entry. In this analysis, cardiovascular disease (CVD) was defined as coronary heart disease (i.e. myocardial infarction (MI), angina pectoris, coronary insufficiency), cerebrovascular disease (i.e. stroke, transient ischemic attack), congestive heart failure, and intermittent claudication. This definition of CVD covers all the manifestations of atherothrombosis, therefore the conclusions directly relate to atherothrombosis. According to this analysis, more than 60% of men and women over 40 years of age will develop atherothrombotic disease at some point in their lives. For patients older than 50 years of age, the development of atherothrombotic disease reduces life expectancy by 11 to 12 years. A 60-year-old man without atherothrombotic disease can expect to live to age 80, whereas the same person who has a history of acute MI can expect to live only an additional 10.8 years. A 60-year-old man with a history of stroke or congestive heart failure has a life expectancy of 7.98 years or four years, respectively. Although not shown on the slide, the life expectancy of a woman with cardiovascular disease is slightly longer than that of a man, but life expectancy is still significantly shorter in the presenc