肿瘤靶向递药新策略的研究进展.pdf

272 药学学报 Acta Pharmaceutica Sinica 20 16, 51 (2): 272 280 瘤靶向递药新策略的研究进展 1 2* 高会乐 , 蒋新国 (1. 四川大学华西药学院, 靶向药物与释药系统教育部重点实验室, 四川 成都 61004 1; 2. 复旦大学药学院, 教育部智能化递药重点实验室, 上海 20 1203) 摘要: 肿瘤已成为危害人类健康和生命的第二大疾病。尽管已有多种抗肿瘤药物上市, 但是由于肿瘤靶向性 不佳, 肿瘤内蓄积能力较差, 使得抗肿瘤效果不尽如人意。如何高效地将抗肿瘤药物递送入肿瘤, 提高药物在肿 瘤部位的浓度, 降低其在正常组织中的浓度, 成为制药领域研究的热点。为达到此目的, 研究者设计了多种纳米 靶向递药系统, 并取得了一定的效果。本文将对目前已有的肿瘤靶向递药策略进行综述, 对其中存在的问题进行 讨论。 关键词: 肿瘤; 肿瘤微环境; 递药系统 中图分类号: R943 文献标识码: A 文章编号: 0513-4870 (20 16) 02-0272-09 The development of novel tumor targeting delivery strategy 1 2* GAO Hui-le , JIANG Xin-guo (1. Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, China; 2. Key Laboratory of Smart Drug Delivery, Ministry of Education, School of Pharmacy, Fudan University, Shanghai 201203, China ) Abstract : Tumor is one of the most serious threats for human being. Although many anti-tumor drugs are approved for clinical use, the treatment outcome is still modest because of the poor tumor targeting efficiency and low accumulation in tumor. Therefore, it is important to deliver anti-tumor drug into tumor efficiently, elevate drug concentration in tumor tissues and reduce the drug distribution in normal tissues. And it has