模式识别受体在动脉粥样硬化形成中的作用-大连医科大学学报.pdfVIP

大连医科大学学报 Vol. 30 No.2 寄ï 30 在第2 期 2008 r 4 月 Journal of Dalian Medical University Apr. 2008 模式识别受体在动脉粥样硬化形成中的作用 丁彦春综述，曲鹏审校 (大连医科大学附属第二医院心血管内科，辽宁大连 116027) 摘要:动脉粥样硬化是动脉壁的慢性炎症性疾病。免疫反应参与动脉粥样硬化形成的全过程。先天免疫反应的激 活在动脉粥样硬化形成中具有重要作用。对先天免疫反应及模式识别受体在动脉粥样硬化形成中的作用进行研 究不仅有助于理解动脉粥样硬化形成过程，而且还能通过直接干扰动脉粥样硬化形成中的炎症反应过程来提供抗 动脉粥样硬化治疗的新方案、新策略。本文对此作一综述。 关键词:动脉粥样硬化;先天免疫;炎症;模式识别受体 中图分类号:R54 1. 4 文献标识码:A 文章编号:1671 -7295(2008)02 -0175 -04 Role of pattern recognition receptors in atherogenesis DING Yan - chun , QU Peng (Department 0/ Cardiology , the Second Affiliαted Hospital 0/ Dalian Medical Univers町， Dαlian 116027 Chinα) Abstract: Atherosclerosis is an inflammatory disease characterized by chronic inflammation in the artery wal l. Immune re- sponses participate in every phase of atherosclerosis. It now appears that activation of innate immune responses play a major role in atheroselerotic lesion development. This review focuses on the role of innate immune response and pattern recogni- tion receptors in the development and progression of atherosclerosis. The involvement of these specific receptors in athero- genesis will not only help us to better understand of the pathogenesis of atherosclerosis , but it also provides new strategies for therapeutie manipulation that could ameliorate the atherosclerotic inflammatory response direetly. Key words: atherosclerosis; innate immune; inflammation ;pattern recognition receptors 先天免疫系统是机体防御病原体入侵的第一道防线，它 因，炎症过程参与动脉粥样硬化形成从内皮细胞被氧化修饰 通过特殊的模式识别受体(pattern - recognition recepto凹， 的脂质激活到最终的斑块破裂的全部过程l2J 。 PRRs) 感知病原体关联的分子模式(pathogen