HBsAg、HBeAg定量检测在慢性乙型肝炎抗病毒治疗中的临床意义.pdf

· 论 著 ·33 HBsAg、HBeAg~量检测在慢性乙型肝炎 抗病毒治疗中的临床意义 李勤英 (衡水市第三人民医院肝二科，衡水053000) 摘要：目的 探讨HBsAg、HBeAg定量检测在CHB抗病毒治疗中的临床意义。方法 选择本院门诊及住 院CHB患者152例，应用干扰素、核苷 (酸)类似物抗病毒治疗，在治疗前、12周、24周、52周定量 检~UHBsAg、HBeAg、HBVDNA定量，观察HBsAg、HBeAg与治疗疗效的相关性。结果 干扰素治 疗组12周HBeAg的变化及24周HBsAg变化与治疗远期效果有相关性，差异均有统计学意义 (P均 0．05)；核苷类似物治疗组HBsAg定量在治疗过程中变化不明显，12周、24周HBeAg变化与患者预后 有关，差异均有统计学意义 (P均0．05)，HBeAg可做为预测耐药风险的参考指标。结论HBsAg、 HBeAg是两个稳定、可靠的生物学标志，两者定量检测可以直观地分析患者病情变化，预测治疗应答 情况，帮助制定个体化治疗方案。 关键词：干扰素；核苷 (酸)类似物；临床疗效 ClinicalsignitieanceofHBsAgandrm eAgquantitativedetectioninchronichepatitisBantiviraltreatment LIQin—ying(SecondDepartmentofLiverDiseases，ThirdPeople HospitalofHengshui,Hebei053000, China) Abstract：ObjectiveTostudytheclinicalsignificanceofHBsAgandHBeAgquantitativedetectionin antiviraltreatment．M ethodsTotalof152patientswith chronichepatitisB selectedfrom theauthor’S hospitalreceivedantiviraltreatmentwithinterferonandnucleosideanalogues．After12weeks，24weeks nad52weeksoftreatment，quna titativedetectionsofHBsAg，HBeAgandHBV DNAhavebeencarriedout SOastoobservethecorrelationbetweenthequantitativedetectionandthetreatmenteffect．ResultsForthe interferontreamt entgroup：thechangesofHBeAgafter12weeksandHBeAgafter24weekshavecorrelation wihtlong-termoutcome，whichisofstatisticalsignificance(bothP 0．05)；forthenucleosidenaalogues rteamt entrgoup：HBsAgquantitativedidn’tchna gesignificantlyinthecourseoftreatment，andthechanges ofHBeAgafter12weeksand24weekshavebeenfoundtobeassociatedwiht theprognosisofthepatients， whichalsohasstatisticalsignificnace(bothP 0．05)；HBeAgcanserveasareferenceindexforforecasting theriskofdrugresistance．ConclusionsHBsAgandHBeAgaretwostableandreliablebiologicalmarkers； thequantitativedetectioncanvisuallyanalyzethepatients’conditionalchanges，predicttherapeuticresponse andhetpfomr ulatetheindividualizedrteamt entplna． Keywords：Interferon；Nucleosidenaalogues；Clinicaleffect 抗病毒治疗是CH