肠道短链脂肪酸产生机制及生理功能的研究进展-广东农业科学.pdf

广东农业科学 2013 年第 11 期 99 肠道短链脂肪酸产生机制及生理功能的研究进展 1,2 1 1 1 1 松珍 张 雁 张名位 孙远明 魏振承 1.广东省农科院蚕业与农产品加工研究所袁广东 广州 510640曰2 华南农业大学食品学院袁广东 广州 510642冤 摘要 人体内短链脂肪酸主要由未消化吸收的的碳水化合物经结肠厌氧菌酵解产生袁主要包括乙酸尧丙酸尧丁酸遥 短链脂肪 酸在结肠腔内不仅可作为肠粘膜细胞的主要能量来源袁还可以减少 炎因子的生成袁降低结肠炎症的发生曰更重要的是袁短链脂肪 酸对肿瘤细胞的增殖能起到抑制作用袁并诱导肿瘤细胞的分化和凋亡袁降低癌变的机率遥对短链脂肪酸的产生机制尧吸收代谢及肠 道内的生理功效进行概述袁为临床营养实践提供依据遥 关键词 短链脂肪酸曰产生曰肠道曰功效 中图分类号 TS255.1 文献标识码 A 文章编号 1004-874X 2013冤11-0099-05 Research progress on producing mechanism and physiological functions of intestinal short chain fatty acids 1,2 1 1 1 1 LIU Song-zhen , ZHANG Yan , ZHANG Ming-wei , SUN Y uan-ming , W EI Zhen-cheng 1.Sericulture and Processing Research Ins titute, Guangdong A cade my of A gricultural Sc ie nces, G uangz hou 510640, China; 2.College of Food Science , South China A gricultural Unive rsity, G uangz hou 510642, China冤 Abstract: Short chain fatty acids such as acetic acid, propionic acid, butyric acid in human body are mainly produced by anaerobic glycolysis colon from un -digested carbohydrates. Short chain fatty acids in the colonic lumen can not only be used as the main energy source of the intestinal mucosal cells, but also reduce the generation of pro -inflammatory cytokines and colitis. Whats more, the short chain fatty acids can play a role in inhibiting tumor cell proliferation, inducing tumor cell differentiation and apoptosis, as well as decreasing carcinogenesis probability