【精选】(unit 12 原文)胶质纤维酸性蛋白作为全身低温治疗新生儿缺氧缺血性脑病的生物标志物.pdf

SMFM Papers www.AJOG.org Glial fibrillary acidic protein as a biomarker for neonatal hypoxic-ischemic encephalopathy treated with whole-body cooling Christopher S. Ennen, MD, LCDR, MC, USN; Thierry A. G. M. Huisman, MD; William J. Savage, MD; Frances J. Northington, MD; Jacky M. Jennings, PhD, MPH; Allen D. Everett, MD; Ernest M. Graham, MD OBJECTIVE: Glial fibrillary acidic protein (GFAP) is specific to astrocytes vated GFAP levels compared with neonates with HIE and normal in the central nervous system. We hypothesized that serum GFAP would imaging. be increased in neonates with hypoxic-ischemic encephalopathy (HIE) treated with whole-body cooling. CONCLUSION: Serum GFAP levels during the first week of life were STUDY DESIGN: We measured GFAP at birth and daily for up to 7 days increased in neonates with HIE and were predictive of brain injury on for neonates in the intensive care unit. We compared neonates with HIE MRI. Biomarkers such as GFAP could help triage neonates with HIE treated with whole-body cooling to gestational age–matched controls to treatment, measure treatment efficacy, and provide prognostic without neurological injury and neonates with HIE by brain abnormalities information. on magnetic resonance imaging (MRI). RESULTS: Neonates with HIE had increased GFAP levels compared Key words: fetal acidosis, glial fibrillary acidic protein, hypoxic- with controls. Neonates with HIE and abnormal brain imaging had ele- ischemic encephalopathy, neonatal seizures, whole-body cooling Cite this article as: Ennen CS, Huisman TAGM, Savage WJ, et al. Glial fibrillary acidic protein as a biomarker for neonatal hypoxic-ischemic encephalopathy treated with whole-body cooling. Am J Obstet Gyne