沙门菌感染流行病学及对喹诺酮耐药研究进展.PDF

·282· 传染病信息  2017年10月30日  第30卷  第5期  Infect Dis Info, Vol. 30, No. 5, October 30, 2017 沙门菌感染流行病学及对喹诺酮耐药研究进展 顾　兵，秦婷婷     [摘要]　沙门菌感染是全球重大的公共卫生问题，沙门菌耐药菌株的逐渐增多给沙门菌病治疗带来了极大困难，成为 公共健康的一大威胁。本文就沙门菌感染的流行病学和对喹诺酮耐药机制研究现状进行综述，为沙门菌的感控防控工作的开 展提供参考。     [关键词]　沙门菌；感染；喹诺酮类；耐药     [中国图书资料分类号]　R446.5；R378.2　　　　[文献标志码]　A　　　　[文章编号]  1007-8134(2017)05-0282-04　   　　DOI:10.3969/j.issn.1007-8134.2017.05.009 Epidemiology of Salmonella infection and progress of quinolone resistance * GU Bing , QIN Ting-ting Department of Laboratory Medicine, Affiliated Hospital of Xuzhou Medical University, 221002, China Medical Technology Institute of Xuzhou Medical University, 221004, China Department of Biological Sciences, Purdue University, West Lafayette, 47907, USA *Corresponding author, E-mail: g163.com 　　[Abstract]　Salmonella infection is a major public health problem in the world. The gradual increase of Salmonella resistant strains has brought great difficulties to the treatment of Salmonella disease and becomes a major threat to public health. This review focuses on the epidemiology of Salmonella infection and the research status of quinolone resistance mechanisms, in an attempt to provide evidence for the prevention, control and treatment of Salmonella infection. 　　[Key words]　Salmonella; infection; quinolones; resistance 8030 15 [2] 　　沙门菌是威胁人类生命健康的重要病原菌， 万例为食源性感染，约有 万例死亡 。目 广泛存在于自然界。全球范围内沙门菌感染形势 前，世界各国由沙门菌引起的食源性感染仍不容 依然十分严峻，在南非、印度及亚洲亚大陆等欠 乐观，不乏相关报道，沙门菌已被世界各国列为 发达地区更为严重[1-2] 。据美国2016 年CDC 数据 首选控制的食源性致病菌。据报道，沙门菌是美 统计，沙门菌每年约引起100 万例患者发病，其 国食源性疾病暴发最常见