不同剂量丙种球蛋白治疗重症手足口病患儿疗效研究.docVIP

不同剂量丙种球蛋白治疗重症手足口病患儿疗效研究 　　[摘要] 目的 探讨不同剂量的丙种球蛋白治疗重症手足口病患儿的疗效。 方法 选取2009年3月～2013年3月来院就诊的重症手足口病患儿97例，分为3组。在基础治疗的基础上，A组给予IVIG 0.2 g/（kgd）治疗；B组予IVIG 1g/（kgd）治疗。C组予羚羊角粉治疗。结果 A、B两组患者NSS好转、发热缓解、临床治愈时间比较，差异均无统计学意义（P0.05）。A、B两组与C组比较，NSS好转、发热缓解、临床治愈时间比较，差异均有统计学意义（P0.05）。 结论 及早使用IVIG对手足口病患儿疗效显著；使用大、小剂量IVIG治疗重症手足口病疗效相近。 [关键词]丙种球蛋白；重症手足口病；疗效 [中图分类号] R729 [文献标识码] B [文章编号] 2095-0616（2013）13-71-02 Analysis of different dose of gamma globulin in treatment of severe HFMD effect YU Huajuan1 LIANG Yinzhi2 1.Department of Pediatrics，Long’an County People’s Hospital，Long’an 532700，China；2.Department of Preventive Care， Long’an County People’s Hospital， Long’an 532700，China [Abstract] Objective To study the curative effect of children with different dose of gamma globulin in the treatment of severe hand-foot-mouth disease. Methods 97 cases in the hospital with severe hand foot and mouth disease in，from 2009 March to 2013 March were divided into 3 groups.On the basis of conventional treatment， A group was given IVIG 0.2g/（kg .d） treatment；group B was treated with IVIG 1g/（kg .d） treatment.C group was treated with antelope horn powder. Results NSS improving， fever，alleviate clinical cure time comparison between A and Bgroup，the difference was not statistically significant（P0.05）.But NSS improved，fever，alleviate clinical cure time comparison among A，B two group and C group，the differences were statistically significant（P0.05）. Conclusion Early use of IVIG significantly in children with hand-foot-and-mouth disease curative has effect；The use of large， small doses of IVIG had similar effect in treatment of severe hand-foot-mouth disease. [Key words] Gamma globulin；Hand-foot-and-mouth disease；Curative effect 手足口病（Hand-foot-mouth Disease，HFMD）是由多种肠道病毒引发的急性的传染病，主要临床特征为发热、口腔疼痛性水疱以及手足疱疹，是一种比较常见的儿科传染病。本病传染性强，传播快，短时间可造成大流行[1]。本研究选取2009年3月～2013年3月来院就诊的重症手足口病患儿87例，采用不同剂量的丙种球蛋白（IVIG）治疗，报道如下。 1 资料与方法 1.1 一般资料 选取2009年3月～2013年3月来院就诊的重症手足口病患儿87例，所有患儿皆符合我《手足口病诊疗指南（2010年版）》中的重症