Correlation between PPARγ protein expression level in granulosa cells and pregnancy rate in IVF program.pdf

Iran J Reprod Med Vol. 10. No.2. pp: 149-154, March 2012 Short communication Correlation between PPARγ protein expression level in granulosa cells and pregnancy rate in IVF program Mehdi Sahmani1 Ph.D., Reza Najafipour 2 Ph.D., M.P.H., Laya Farzadi3 M.D., Ebrahim Sakhinia1 1 3 1 1 Ph.D., Masoud Darabi Ph.D., Vahideh Shahnazi B.Sc., Amir Mehdizadeh M.Sc., Maghsod Shaaker M.Sc., Mohammad Noori4 Ph.D. 1 Department of Biochemistry and Abstract Clinical Laboratories, Faculty of Background: Peroxisome proliferative-activated receptors (PPARs) are nuclear Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. receptors that involved in cellular lipid metabolism and differentiation. The subtype 2 Department of Clinical γ of the PPAR family (PPARγ) plays important roles in physiologic functions of Biochemistry and Molecular and ovaries. Cellular Research Center, Objective: To determine correlation between PPARγ protein level in granulosa cells Ghazvin University of Medical Sciences, Qazvin, Iran. and pregnancy rate in women undergoing in-vitro fertilization (IVF) treatment. 3 Women’s Reproductive Health Materials and Methods: In this cross-sectional study, twenty-five samples of Research Center, Alzahra granulosa cells were collected from women referred to an IVF treatment center. Hospital, Tabriz University of PPARγ protein expression level in granulosa cells was determined in comparison Medical Sciences, Tabriz, Iran. 4 Drug Applied Research C