房颤与猝死致病新基因NUP155的发现_王擎.ppt

房颤(Atrial Fibrillation, AF) 房颤是临床最常见的持续性心律失常 据统计，人群患病率接近1%，在美国影响300万人 我国患者高达1300万 危害极大，大大提高患者死亡率和脑中风的发生率。 Genetic Loci and Genes for AF Genetic Loci and Genes for AF Genetic Component of Complex AF 1. Framingham Heart Study (2,234 offsprings): Risk ratio (RR) = 1.85 for offsprings if at least one parent has AF OR = 3.23 with study participants younger than 75 years or to 3.17 when offsprings with overt heart disease were excluded. 2. Icelandic Study (5,269 AF patients and 10,000 controls ): RR = 1.77 for the first-degree relatives = 1.36 for the second-degree relative = 4.67 for first-degree relatives under the age of 60 years 3. MGH Study (110 patients with lone AF ) RR = 8.1 for sons, 9.5 for daughters, 70 for brothers, 34 for sisters, 4 for mothers, and 2 for fathers17 Association of SNPs on Chromosome 16q22 with AF Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry. Benjamin EJ et al Nat Genet. 2009 Aug;41(8):879-81. Epub 2009 Jul 13. National Heart, Lung, and Blood Institutes Framingham Heart Study ; replicated this association in an independent cohort from the German AF Network A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke. Gudbjartsson DFStefansson K. Nat Genet. 2009 Aug;41(8):876-8. Epub 2009 Jul 13. Iceland, replicated in Norway and the United States populations Not associated with AF in a Chinese population Highly Significant Association of a Chromosome 4q25 SNP with Atrial Fibrillation in a Chinese Population Brief Title: Association of a 4q25 SNP with AF in a Chinese Population Lisong Shi, PhD,*? Cong Li, BS,*? Chuchu Wang, BS,*? Yunlong Xia, MD,§? Gang Wu, MD,||? Fan Wang, BS,* Yanzong Yang, MD,§ Bo Yang, MD,|| Chengqi Xu, BS,* Mugen Liu, PhD,* Jingyu Liu, PhD,* Xiang Ren, PhD,* Qiutang Zeng, MD,? Xin Tu, MD, PhD,* Qing Kenneth Wang*?, PhD, M.B.A. Human Genetics 2009, In press 2009 Aug 26. [Epub ahead of print] Allelic association of rs22007