基于个性化脉搏波传导参数的连续血压测量方法研究.docx

研究论著RESEARCH WORK基于个性化脉搏波传导参数的连续血压 测量方法研究Research on the Continuous Blood Pressure MeasurementMethod Based on Personalized Pulse Wave TransmissionParameters董骁，宾光宇，吴水才北京工业大学 生命科学与生物工程学院, 北京 100124DONG Xiao, BIN Guang-yu, WU Shui-caiSchool of Life Science andBioengineering,Beijing University of Technology,Beijing100124, China[摘 要] 目的 建立基于个性化脉搏波传导参数的连续血压测量方法模型。方法对18名受试者进行了运动实验，在运动实验过程中连续记录受试者的心电和手指容积脉搏波，同时利用动态血压计每2min采集受试者的血压；每个受试者间隔1周的时间进行第二次实验；采用最小均方误差线性估计的方法来建立脉搏波传导时间和收缩压之间的线性模型。结果同一个受试者脉搏波传导时间与收缩压具有良好的线性关系（r2=0.91±0.06），线性模型的检测误差为（3.48±1.69）mmHg，且具有较好的稳定性。但对于不同受试者，很难建立统一的线性模型（r2=0.14）。结论 基于个性化脉搏波传导参数的连续血压测量方法是可行的，有望实现无袖带的连续血压测量。[关键词] 动脉压；脉搏波；传导参数；收缩压Abstract:ObjectiveToestablishacontinuousbloodpressuremeasurementmodelbasedonpersonalizedpulse wave transmission parameters. Methods ECG parameters and fi nger pulse waves of 18subjectswerecontinuouslymeasuredandrecordedinexercisetestsandtheirbloodpressures(BP)werealsorecordedevery2minuteswithdynamicBPmonitor.Theexercisetestsofallthe18subjectswereconductedrepeatedlyoneweeklater.Alinearmodelbetweenpulsewavetranslationtime(PWTT)and systolicbloodpressure(SBP)wasconstitutedthroughlinearminimummeansquareerrorestimation.Results There is a good linear relationship between PWTT and SBP of the same subject(r2=0.91±0.06)andthetesterrorofthelinearmodelwithnicestabilityis(3.48±1.69)mmHg.However,itisverydif fi cult to build a uni fi ed linear model for all subjects (r2=0.14). Conclusion It is feasible tomeasure bloodpressurecontinuouslybasedonpersonalizedpulsewavetransmissionparameters,whichcancontribute to the realization of sleeveless continuous blood pressure measurement.Key words: arterial blood pressure; pulse wave; transmission parameters; systolic blood pressure[中图分类号] TN911.7 [文献标志码] A doi：10.3969/j.issn.1674-1633.2014.10.007 [文章编号] 1674-1633(2014)10-0024-040 前言动脉压（ABP）是反映人体循环机能的重要生理参数，同时也是临床上诊断疾病、观察治疗效果、进行预后判断的重要依据[1-3]。动脉压测量的方法有两大类，即直接测量法和间接测量法[4]。直接测量法即在动脉腔内置管测量内压力，一直被认作是临床血压测量的“金标准”[5]。间接测量法即无创测量，分为间断和连续两类。传统的间断测量方法有示波法