HPV研究动态.ppt

The role of TLRs in cervical cancer with HPV infection: a reviewXiao Yang1, Yanxiang Cheng1,2 and Chunsheng Li2宾夕法尼亚大学医学院,武汉大学人民医院在HPV感染的宫颈癌的作用：回顾TLRsPPT制作人：熊珍平（本文为综述类论文）学号：2016128337 引自：/sigtrans Signal Transduction and Targeted Therapy (2017) 2, e17055; doi:10.1038/sigtrans.2017.55; published online 3 November 2017 信号转导及靶向治疗（2017）2，e17055；DOI：10.1038/sigtrans.2017.55；2017年11月3日在线发表 摘要 The main cause of cervical cancer is persistent infection with high-risk human papilloma virus (HR-HPV), but not all human papilloma virus (HPV) infections lead to cervical cancer. The key factors that determine the outcome of HPV infection remain poorly understood, and how the host immune system protects against HPV infection is unclear. Toll-like receptors (TLRs) are a group of pattern recognition receptors present in the cytoplasm and cell membrane, and can specifically recognize pathogen-associated molecular patterns. As the key molecules of innate and acquired immunity, TLRs not only play important roles in the immune defense against infectious diseases, but also are involved in the occurrence and development of a variety of malignant tumors. In cervical cancer caused by HR-HPV infection, TLRs have been found to regulate the local immune microenvironment. The role of TLRs in HR-HPV infection and HPV-induced cervical cancer and its relationship with HPV vaccine are reviewed in this article. 宫颈癌的主要病因是高危型人乳头状瘤病毒（HPV）的持续感染，但并不是所有的人类乳头瘤病毒（HPV）感染导致宫颈癌。决定HPV感染结果的关键因素尚不清楚，宿主免疫系统对HPV感染的保护机制尚不清楚。Toll样受体（TLR）是一组模式识别受体存在于细胞质和细胞膜，并能特异性地识别病原体相关分子模式。作为天然免疫和获得性免疫的关键分子，TLRs不仅起着重要的作用，在免疫防御传染病，但也参与了多种恶性肿瘤的发生和发展。在宫颈癌的HPV感染引起，Toll样受体已被发现调节局部免疫微环境。在HPV感染和HPV的作用TLRs诱导宫颈癌与HPV疫苗的关系作一综述。 研究背景 Cervical cancer is one of the most common gynecological malignancies. The incidence of cervical cancer ranks second among women, and is a serious threat to womens health.1 Nearly all cervical cancer is caused by high-risk human papilloma virus (HR-HPV) infection, mainly HPV16 and HPV18.2 In most cases of huma