下丘脑室旁核胃动素对消化功能影响的(英文).pdfVIP

460 · · 现代生物医学进展 Progress in Modern Biomedicine Vol.11 NO.3 FEB.2011 The Impact study of motilin digestive function in hypothalamus paraventricular nucleus* △ CUI Hai-yan, XU Luo , ZHOU Hai-feng (Dep artment of Pathophysiology, Medical College of Qingdao University, Qingdao, 26602 1 China) ABSTRACT Obj ective: To investigate the effects of paraventricular hypothalamic nucleus PVN administration of motilin and （ ） motilin receptor antagonist GM-109 on ingestion and body weight gain in rats. Methods: Motilin and GM- 109 were injected in PVN at doses of 0.005-5 nmol. A significant increasing ingestion was observed 1h after PVN injection motilin 3nmol/rat and continued for 2h. Ingestion was measured by decreasing of pellets between the preweighted pellets and the uneaten pellets at 20 min, 1 and 2 h after drug. The mice were weighted .Daily PVN administration of motilin and GM-109, the weight of the rats were detected for 1week. Body weight, food intake were analyzed and compared with those of the rats of ACSF (NaCl, 138.9 mmol;KCl, 3.4 mmol; CaCl , 1.26 mmol; NaHCO , 2 3 4 mmol;NaH PO 2H O, 0.6 mmol; and glucose, 5.6- mmol)-treated controls. Results: PVN administration of motilin 5nmol/rat increased · 2 4 2 significantly the food intake after 1 and 2 h. The body weight increased 7days later. Food intake increased significantly (p ＜0.01)