薏米黄酒的急性毒性.pdfVIP

867 现代生物医学进展 Progress in Modern Biomedicine Vol.11 NO.5 MAR.2011 · · 薏米黄酒的急性毒性研究* 1 2 2 2 2 2 吴 海 申可佳 谭周进 朱 伟 李 珊 蔡 锐 1 2009 410208 2 410208 （湖南中医药大学 级硕士研究生班 湖南长沙 ；湖南中医药大学基础医学院湖南长沙 ） 摘要目的：研究薏米黄酒的急性毒性，评价该酒的食用安全性。方法：以ICR 小鼠为受试对象，一次性给予最大剂量，观察薏米黄 酒对小鼠的急性毒性反应，测定薏米黄酒的LD50 和最大耐受剂量。结果：小鼠无一只死亡，无法测出LD50 ，最大耐受量大于 20400 mg/kg。结论：实验检测表明，该黄酒无毒，为薏米黄酒的应用提供了毒理学依据。 关键词：薏米黄酒；急性毒性；动物实验 TS262.4 A 1673-6273 2011 05-867-03 中图分类号： 文献标识码： 文章编号： （ ） Acute Toxicity Test of Coix Seed Yellow Rice Wine* 1 2 2△ 2 2 2 WU Hai , SHEN Ke-j ia , TAN Zhou -j in ,ZHU Wei , LI Shan , CAI Rui ( 1 2009 Postgraduate Courses,Hunan University of Traditional Chinese Medicine,Changsha,Hunan,China 4 10208; ， 2 College of Basic Medicine,TCM University of Hunan, Changsha, China, 4 10208) ABSTRACT Obj ective: To investigate the acute toxicity of coix seed yellow rice wine, and to evaluate the consumption safety of the yellow rice wine. Methods: Maximum dose was given once to ICR mice for detecting acute toxicity of the mice, the LD50 ofthe coix seed rice wine. The largest quantity of administration was detected. Results: There were no mice death and LD50 of the yellow rice wine was not detected. The largest amount of the drug was more than 20400