左氧氟沙星治疗社区获得性肺炎疗效观察.pdfVIP

中国热带医学 2012 年第12卷第9 期 China Tropical Medicine，September 2012 ，Vol. 12，No.9 ·1139 · ·短篇论著· 左氧氟沙星治疗社区获得性肺炎疗效观察 王力锋 摘要：目的 比较左氧氟沙星与头孢呋辛联合阿奇霉素治疗社区获得性肺炎（CAP）的临床疗效、细菌清除率和安 全性。方法 将57 例社区获得性肺炎随机分为左氧氟沙星治疗组（31 例）和头孢呋辛联合阿奇霉素对照组（26 例），观 察两组患者的临床疗效，细菌清除率和不良反应。结果 57 例CAP 患者中左氧氟沙星租治疗的痊愈率和有效率分别 为70.96%和93.54% ，细菌清除率为88.89% ，药物不良反应发生率为12.90% ；对照组治疗的痊愈率和有效率分别为 69.23%和92.31% ，细菌清除率为85.71% ，药物不良反应发生率为11.54% 。两组比较差异无统计学意义，平均疗程、住 院天数差异亦无统计学意义。结论 左氧氟沙星治疗CAP 临床疗效确切，患者依从性好，药物不良反应较低，值得临 床推广应用。 关键词：左氧氟沙星；头孢呋辛；阿奇霉素；社区获得性肺炎 中图分类号：R563.1 文献标识码：A 文章编号：1009-9727(2012)9-1139-03 Comparison of effect of levofloxacin with cefuroxime plus azithromycin on community-acquired Pneumonia. WANG Li-feng.(WenchengtownshipHospital,Wenchang571300,Hainan,P.R.China) Abstract:Objective To evaluate the efficacy of levofloxacin with cefuroxime plus azithromycin in treatment of community-acquired pneumonia (CAP). Methods Fifty- seven CAP patients were randomly divided into levofloxacin groups treated with levofloxacin alone and control group treated with cefuroxime plus azithromyicn, and the efficacy, side effects in both groups were observed. Results The cure and efficacy ratea in the levoploxacin treatment group were 70.96% and 93.54% respectively. The eradieation rates of pathogens was 88.89%. The incidence of adverse drug reaction was 12.90%. In cefuroxime and azithromycin combination group, the cure and efficacy rate were 69.23% and 92.31% reapectively. The eradication rates of pathogens was 85.71% . The incidence of adverse reaction rate was 11.54% . There was no significant difference between the two groups in term of these parameters. The mean duratoion of treatment and days of ho