比索洛尔联合坎地沙坦治疗慢性充血性心力衰竭患者的疗效观察.pdfVIP

比索洛尔联合坎地沙坦治疗慢性充血性心力衰竭患者的疗效观察 郑云龙，唐方明，陈冠鹏，梁普博 （广东省农垦中心医院心内科，广东湛江 524002） 摘　要：目的 观察比索洛尔联合坎地沙坦治疗慢性充血性心力衰竭的疗效。方法 68例慢性充血性心力衰竭患者随 机分为治疗组和对照组。在常规治疗的基础上，对照组口服坎地沙坦，治疗组口服坎地沙坦和比索洛尔，治疗24周后 观察心功能情况及左室射血分数、心率、6 min步行距离和N端B型脑钠肽前体(NT-proBNP)水平。结果 治疗组的心功能 改善明显优于对照组(P0.05) ；两组治疗后的左室射血分数、心率、6 min步行距离、NT-proBNP水平差异有统计学意义 (P0.01) 。结论 比索洛尔联合坎地沙坦治疗慢性充血性心力衰竭可取得较好疗效。 关键词：慢性心力衰竭；比索洛尔；坎地沙坦 + 中图分类号：R 541.6 1 文献标识码：A 文章编号：1005-4057(2011)02-0132-03 DOI:10.3969/j.issn.1005-4057.2011.02.005 Chroniccongestiveheartfailuretreatedwithbisoprololandcandesartan ZHENG Yun-long, TANG Fang-ming, CHEN Guan-peng, LIANG Pu-bo (Cardiovascular Department, Central Hospital of Guangdong Province Agriculture Reclamation, Zhanjiang 524002, China) Abstract:Objective To observe the clinical efficacy of bisoprolol plus candesartan in the treatment of chronic congestive heart failure (CCHF). Methods Sixty-eight patients with CCHF were randomly divided into treatment and control groups. Based on the conventional therapy, control group received oral candesartan, while treatment group accepted candesartan and bisoprolol. The heart function, left ventricular ejection fraction (LVEF), heart rate, 6-minute walking distance and N-terminal pro –B-type natriuretic peptide (NT-proBNP) level were detected after 24-week treatment. Results The improvement of heart function in treatment group was superior to that in control group (P0.05). There were significant differences in LVEF, heart rate, 6-minute walking distance and NT-proBNP content between both groups (P0.01). Conclusion The combination of bisoprolol and candesartan can achieve the satisfactory efficacy in CCHF. Keywords:chronic heart failure; bisoprolol; candesartan 20世纪80年代以来人们对心力衰竭发生机制的 [1]