丙种球蛋白被动免疫治疗原因不明性反复自然流产研究.pdfVIP

# 3260# 2007 22 陈巧儿 秦卫兵 叶嘉玲 杨 宁 王一峰 刘玉兰 许玉芳 510600 R714121 A 1001-4411 (2007) 23-3260-03 = : ( URSA ) T Th 1/Th 2NK , : URSA , 2 10 g, 4 3, 26~ 30 FACSC alibur 25 T Th1/Th2 NK, 20: 25 URSA 4 + 1921, 4, 4% CD 3 T + + + + ; CD T ; CD 4 T; CD 4 /CD Th 2 IL- 10; Th 1 IFN - C NK: URSA , = The treatment of unexplained recurrent spontaneous abortion omen ith intrave- nous immunoglobulin CHEN Qiao- Er, QIN Wei- Bing, YE Jia- L ing, et al1Family Planning Research Institute of uangdong, uangzhou 510600, China 1Abstract2 Objective: To investigate the effectiveness and the changes of b lock ing antibody, T lymphocyte subpopulations, intra- cellular Th1/Th2 cytok ines and NK cell percentage of treatm ent w ith intravenous mi munoglobu lin in unexp lained recurrent spontaneous abor- tionw omen1M ethods: 25w om enw ere received treatm en tw ith mi munoglobu lin at a dose of 10 g w ithin 2w eeks for 4 tmi es before pregnan- cy. Once conceptionw as ach ieved, mi munoglobu lin treatm en tw as continued on 3 m onth ly basis at sam e dosew ith in 3w eeks through 26~ 30 w eeks of gestation. Flow cytometry w as used to m easure T lymphocyte subpopu lations and intracellular Th1/Th2 cytokines and NK cell per- centage of allw om en participantsw ith RSA1Results: Of 25w om en continued mi munoglobu lin treatm en t through 26~ 30 weeks of gestation, there are 19 CDC positive after mi m unotherapy, 21 ( 4% ) had a successfu l term pregnancy. W e have also observed mi munizedwom enw ith + + + RSA show ed sign ific