内源性含硫气体分子的心血管调节（英文）-.ppt

H2S and Cardiovascular Diseases Hypertension Hypoxic pulmonary hypertension Pulmonary blood flow-induced pulmonary hypertension Vascular calcification Hyperhomocysteinemia (HHcy) Endotoxic and septic shock Myocardial injury coronary artery disease Endogenous H2S production was reduced in ISO-induced myocardial injury H2S Myocardial injury 1 Plasma H2S level ↓ 2 H2S production in the heart↓ 3 CSEmRNA expression↑ Biochem Biophys Res Co, 318 (2004) 756–763 H2S protects the structure and the contractility of the myocardium The mechanism is associated with the getting rid of free radicals H2S Myocardial injury Biochem Biophys Res Co, 318 (2004) 756–763 Endogenous H2S production was inhibited in cardiomyopathy induced by adriamycin (ADR) Plasma H2S level H2S content in rat heart H2S Myocardial injury NaHS-treatment improved ADR-induced depression of cardiac functions ADR+NaHS-L ADR+NaHS-H H2S Myocardial injury NaHS-treatment lessened ADR-induced myocardial damage control ADR ADR+H2S-L ADR+H2S-H control ADR ADR+NaHS-L ADR+NaHS-H H2S Myocardial injury * Endogenous Sulfur-containing Gaseous Molecules Cardiovascular Regulation Du Junbao, Tang Chaoshu Peking University Health Sciences Center, China Continuous generation Fast transmission Extensive action Short half life time Low molecular weight E H2S Synthesis and Distribution Intrinsic H2S content: Rat serum concentration: 45.6 ±14.2 μM H2S level in different blood vessels: Thoracic aorta: 33.70±2.2 Portal vein: 19.60±2.8 Pulmonary artery: 5.31±0.7 Mesenteric artery: 6.17±0.56 Coccygeal artery: 8.12±0.85 (pmol/min/mg protein) H2S in myocardial tissues: 　 18.64 ±4.49 pmol/min/mg wet tissue CSE shows expression in cardiovascular system EMBO J, 2001; BBRC 1997, 2004; J Infect 2004 H2S is endogenously produced in cardiovascular system Modulates cardiac contractility Modulate proliferation and apoptosis of the vascular smooth muscl