心脏辅助器械发展-中英文课件.ppt

The U.S. Experience with Total Artificial Hearts vs. Left Ventricular Assist Devices HeartMate II 临床研究 有效支持时间 (n=281) 中位数: 155 天 (最长：5年) 平均持续时间: 237 天 181 患者年累积支持 87% 患者出院 78% 带着支持装置 10% 在心脏移植后 (prior to index discharge) 77% 的使用时间(140例年)为院外使用时间 HeartMate II 实际存活曲线 Primary (n=133) and CAP (n=146) Cohorts HeartMate II 临床试验移植后存活率 移植后30天存活率 150/157 (96%) 移植后一年存活率 117/128 (91%) HeartMate II 临床研究致死因素 (56/281) HeartMate II 临床研究不良事件 HeartMate II 临床研究不良事件 不良事件发生率比较HMII (n=281) vs HM VE BTT (n=280)1 HeartMate II 无主要装置失效或置换事件率 (BTT, n=281) 英文原版 The U.S. Experience with Total Artificial Hearts vs. Left Ventricular Assist Devices HeartMate II Clinical Study Support Duration (n=281) Median duration: 155 days (longest: 5.0 yr) Average duration: 237 days 181 pt-years cumulative support 87% patients discharged 78% on device support 10% following transplant (prior to index discharge) 77% of time (140 pt-years) spent out of hospital HeartMate II Actuarial Survival Primary (n=133) and CAP (n=146) Cohorts HeartMate II Clinical TrialPost-transplant Survival 30 Days Post-Transplant 150/157 (96%) One year post-transplant 117/128 (91%) HeartMate II Clinical StudyCauses of Death (56/281) HeartMate II Clinical StudyAdverse Events HeartMate II Clinical StudyAdverse Events Adverse Event Rate ComparisonsHMII (n=281) vs HM VE BTT (n=280)1 HeartMate II Freedom from Major Device Failure or Replacement (BTT, n=281) * As the rotor spins, it is “levitated” into position by the blood flowing through the pump. The hydrodynamic bearing means that no part of the rotor touches the device housing This makes it less vulnerable to wear, heat and thrombus formation. The design also ensures that all areas of the pump are washed out by blood and therefore decreases the risk of thrombogenesis. * * First Permanent Total Artificial Heart Implant-- Dr. Barney Clark What Will The Future Be?? Total Artificial Hearts Left Ventricular Assists Left Ventricular Assist with short term Right Ventricul