模式识别受体与乙肝病毒感染（英文版）.ppt

Nature History of HBV Infection Pattern Recognition Receptors(PRR) Scientific Questions? Function of Myeloid and Plasmacytoid Dendritic Cells of Patients with CHB?? Expression of TLR-3, TLR-9 in patients following HBV chronic infection?? The increase of expression level of TLR3 is slower and delayed in CH groups than HV groups. It contributes to the inability for the host to clear HBV. The level of TBK1 molecular is quite low even following dsRNA stimulation, suggesting that abnormal of signal transduction passway may exist in HBV . Our results suggest that dysfunction of TLR3 might play an important role in chronic HBV infection. It may provide new insights for understanding the mechanism of persistent HBV infection * * Dept of Infectious Diseases Shanghai Ruijin Hospital Jiaotong University School of Medicine Qing Xie Pattern Recognition Receptors and HBV Infection Role of Toll-like Receptors HBsAg rate (%) ?8: high 2-7: medium 2: low HBV infection is still a major global health care problem 350 million chronic carriers worldwide 9th leading causes of death 75% of HBV carrier are Asian High prevelance Widely spread Acute HBV Infection Chronic HBV Infection Chronic Hepatitis B Cirrhosis Liver Failure HCC 3-5% Adult 95% Children 5年 6-15% 5年 20-23% 5年 12-20% Antiviral treatment HBV Virons Complete Response Partially Response Non Response Immune as a key factor influences the outcome and progression of disease Challenge: What mechanism of virus clearance of host?? How to do that?? HBV H O S T Virus clearance resolved Unable to clear virus Persistent infection Progression of disease Immune function of Host Central Role Three essential elements required in liver inflammation following HBV infection HBV VIRONS HEPATOCYTES IMMUNOCYTES Non antigen specific-INNATE IMMUNITY NK/T Phagocytes NK pDC Plasmacytoid DC 调节性T细胞 Antigen specific-ADAPTIVE IMMUNITY CD8 CD4 B Tregs CD4+CD25+ Treg cell LINK Cytokines Type I interferon IL-12 Granzyme B mDC Myelo