唾液酸化Lewis X和半乳糖凝集素-3表达与甲状腺乳头状癌浸润转移的关系唾液酸化Lewis X和半乳糖凝集素-3表达与甲状腺乳头状癌浸润转移的关系.pdf

Asian Case Reports in Oncology 亚洲肿瘤科病例研究, 2017, 6(4), 33-39 Published Online October 2017 in Hans. /journal/acrpo /10.12677/acrpo.2017.64006 Expression of Sialyl Lewis X and Galectin-3 in Papillary Thyroid Carcinoma and Their Relationships with Invasion and Metastasis Peizhong Shang, Runling Nan, Jin Wang, Ana Nie, Yanyan Li, Wei Zhang, Wei Hu, Huaping Gu st Department of General Surgery, The 251 Hospital of Chinese PLA, Zhangjiakou Hebei th th st Received: Aug. 10 , 2017; accepted: Aug. 24 , 2017; published: Aug. 31 , 2017 Abstract Objective: To investigate the expression of sialyl Lewis X (SLeX) and Galectin-3 in papillary thyroid carcinoma and their relationships with the potential of invasion and metastasis. Methods: The ex- pression of SLeX and Galectin-3 in 164 cases of papillary thyroid carcinoma and 30 cases of pa- ra-tumorous tissue were studied by EliVisionTM plus two-step immunohistochemical method. Re- sults: The positive rates of SLeX and Galectin-3 in papillary thyroid carcinoma were 70.7% and 92.1%; those in para-tumorous tissue were 6.7% and 20.0%. Both in papillary thyroid carcinoma were significantly higher than those in para-tumorous tissue (P 0.05). The positive rates of SLeX and Galectin-3 in the patients with tumor invasion were 84.8% and 98.0%; those in the patients without tumor invasion were 49.2% and 83.1%. Both in the patients with tumor invasion were significantly higher than those in the patients without tumor invasion (P 0.05). The positive rates of SLeX and Galectin-3 in the patients with lymphatic metastasis were 89.2% and 96.8%;