IL_1_和IL_6在放射性肺损伤发病中的作用.pdfVIP

18 3 2009 3 194 Acta Academiae Medici ae CPAF Vol18 No3 Mar2009 IL-1和IL-6 在放射性肺损伤发病中的作用 1 1 1 2 郑爱青, 韩晨光, 朱新英 , 王兴武 ( 1武警医学院附属医院肿瘤科, 天津 300162; 2 山东省肿瘤医院基础研究中心, 山东 济南250117) : ( NSCLC) IL- 1IL-6 , 2005 7 - 2005 12 NSCLC , 9 48 , (A ) ( B ) , 812 3 ml, ELISA IL- 1 IL-6 IL- 1A B ( P 001) IL-6 , A 8 12 IL-6 (A B , 8 12 P 001, P 005) IL- 1 IL-6 : -1; -6; 1008-5041(2009)-03-0194-03 R39211 A Effect of cytokines IL-1and IL-6 levels on radiation pulmonary injury ZHENG A-i qin , HAN Chen- uan , ZHU Xin-yin , WANG Xin-wu ( Department of Oncolo y, The Affiliated Hospi- tal of Medical Colle e of Chinese Peoples Armed Police Force, Tianjin 300162, China) Abstract: Objective To i vestigate the effect of circulatory cytoki es IL-1a d IL-6 o radiatio pulmo ary i jury . Meth- ods Forty-eight patie ts with o-small-cell lu g ca cer ( NSCLC) received three-dime sio al co formal radiatio therapy from July 2005 to December 2005, whose follow-up were over 9 mo thsPatie ts were divided to two groups accordi g to their subse- que tly developi g radiatio p eumo itis (group A) or ot (group B) Blood sampleswere take before, duri g radiatio a d up to 12 weeks after-radiatio The IL- 1a d IL-6 co ce tratio was measured before, duri g a d after radiatio treatme t usi g a double a tibody sa dwich e zyme-li ked immu osorbe t assay kitResults IL- 1levels were sig ifica tly higher before radi- atio , at multiple time poi ts duri g radiatio , a d after radiatio for those who developed p eumo itis ( P 001) IL-6 levels fluctuated somewhat with radiatio , a d after completio of radiatio treatme ts eight weeks or twelve weeks, there was a tre d to- ward a i crease of IL-6Conclusions IL- 1a d IL-6 levels may be used as