2型糖尿病患者血、尿渗透压检测对糖尿病肾病早期诊断的临床意义.docVIP

精品论文 参考文献 2型糖尿病患者血、尿渗透压检测对糖尿病肾病早期诊断的临床意义 刘希龙 刘日旭 王亚男（大连大学附属新华医院检验科 辽宁大连 116021） 　　【摘要】目的　探讨2型糖尿病患者的血、尿渗透压检测对糖尿病肾病（DN）的早期诊断和病情监测的临床意义。方法 选取98例2型糖尿病患者，依据患者肾功能指标（尿素氮、肌酐、尿酸）正常与否，将其分为DN早期组67例、DN组31例，选取健康体检者40 例作为对照组，对选取样本进行尿渗透压、血清渗透压检测。结果 DN早期组的尿渗透压、尿／血渗比明显低于对照组，且差异具有统计学意义（Plt;0.05），而血清渗透压差异不具有统计学意义（P＞0.05）。DN组的血清渗透压、尿渗透压、尿／血渗比更是低于对照组，且差异均具有统计学意义（Plt;0.05）。结论 对2型糖尿病患者的血、尿渗透压检测有助于DN的早期诊断和病情监测。 　　【关键词】渗透压 尿／血渗比 2型糖尿病 糖尿病肾病 　　【中图分类号】R587.1 【文献标识码】A 【文章编号】1672-5085（2013）52-0017-02 　　The Clinical Significance of Blood and Urine Osmotic Pressure Test in the Early Diagnosis of Diabetic nephropathy with type 2 Diabetes 　　 Liu Xi-long Liu Ri-xu Wang Ya-nan 　　（Department of Clinical Laboratory in Affiliated xihuan Hosptial of Dalian University,Liaoning Dalian 116021） 　　【Abstract】Objective：To discuss the clinical significance of the urine, blood serum osmotic pressure detection in the early diagnosis of diabetic nephropathy in the type 2 diabetes.Method: According to patients renal function indexes (BUN, Cr, UA) is normal or not, 98 patients with type 2 diabetes can be divided into early DN group 67 cases, DN group 31 cases.The test of blood and urine osmotic pressure were measured in 98 patients with type 2 diabetes and 40 healthy individuals,then compared among the three groups.Result: The results of Urine Osmotic Pressure and Urine-Blood Osmotic in early DN group were lower than those of the healthy group, the differences were all statistically significant (Plt;0.05) ,but the difference of blood osmotic pressure was not statistically significant (P＞0.05)．The results of Urine Osmotic Pressure ，blood osmotic pressure and Urine-Blood Osmotic in DN group were significantly more lower than those of the healthy group, the differences were all statistically significant (Plt;0.05).Conclusion: The detection of Blood and Urine Osmotic Pressure in patients with type 2 diabetes provide the clinical basi