ENA抗体及体液免疫检验对系统性红斑狼疮的诊断及疗效评估意义.docVIP

精品论文 参考文献 ENA抗体及体液免疫检验对系统性红斑狼疮的诊断及疗效评估意义 邵阳市中心医院 湖南邵阳 422000 【摘 要】目的 探讨ENA抗体及体液免疫检验在诊断系统性红斑狼疮（SLE）中的价值及其疗效评估意义。方法 选取我院2014年9月-2016年9月收治的SLE患者31例为研究组，另选取同期来我院体检健康者20例为对照组，均进行ENA抗体及体液免疫检查，分析检测结果。结果 研究组患者的TgG、TgA水平明显高于对照组，C3、C4水平明显低于对照组，组间比较差异均有统计学意义（Plt;0.01）；对照组仅检出1例TgG 阳性和1例C3阳性，其他项目未检出阳性；研究组患者抗dsDNA、抗Sm阳性率以TgG和C3为最高，均为67.7%，其次为TgA，其阳性率为51.6%。结论 ENA抗体及体液免疫检验对准确诊断系统性红斑狼疮和评估其疗效有积极意义。 【关键词】系统性红斑狼疮；ENA抗体；体液免疫 [Abstract] objective to explore the ENA antibody and humoral immunity test in the diagnosis of systemic lupus erythematosus（SLE）value and curative effect evaluation of significance. Methods from September 2014 to September 2014 in SLE patients with 31 patients treated for the team，the other selected in the same period to our hospital check-up 20 cases healthy subjects as control group，were inspected ENA antibody and humoral immunity，analysis of test results. Results the team TgG，TgA level of patients was obviously higher than that of control group，C3 and C4 levels significantly lower than the control group，compare the differences between groups were statistically significant（P lt; 0.01）；Positive control group only 1 case of TgG detection and 1 case of C3 is positive，the other project not detected positive；Anti dsDNA，Sm group patients was the highest positive rate to TgG and C3，are 67.7%，followed by TgA，the positive rate was 51.6%. Conclusion ENA antibody and humoral immunity test for accurate diagnosis of systemic lupus erythematosus（sle）and evaluate its curative effect has positive significance. [Key words] systemic lupus erythematosus（sle）；ENA antibody；The humoral immune 系统性红斑狼疮（systemic lupus erythematosus，SLE）是一种炎症性免疫性疾病，能累及多器官、多系统，青年女性患者居多[1]。主要临床症状有发热、皮疹、肾损害、关节痛、胸膜炎、精神症状等，疾病呈渐进性发展。SLE患者血清中存在大量具有免疫活性的多种自身抗体，有抗可提取抗原抗体（ENA）、抗双链DNA（ds-DNA）、抗核抗体（ANA）等[2]。本研究分析了31例SLE患者的血清抗ENA及体液免疫水平，并与健康对照组比较，旨在探讨ENA及体液免疫检测在SLE中的诊断价值及疗效评估意义，现将结果汇报如下。 1资料与方法 1.1一般资料 本组研究组病例为我院2014年9月-2016年9月收治的SLE患者，共入选31例，均符合1997年美国