2015ACR关于AS治疗指导建议中英翻译.doc

RESULTS（结果） Recommendations for the treatment of patients with active?AS? 对成人活动性AS的治疗建议 A1. Pharmacologic treatment. 药物治疗 In adults with active?AS: We strongly recommend treatment with NSAIDs over no treatment with NSAIDs (PICO 2; lowquality evidence; vote 100% agreement). 对于与成人活动性AS：我们强烈建议使用NSAIDs的治疗胜过不使用NSAIDs治疗（PICO2;低质量的证据;100％表决同意）。 We conditionally recommend continuous treatment with NSAIDs over on-demand treatment with NSAIDs (PICO 1; very low-quality evidence; vote 90% agreement). 我们建议（非绝对地）NSAID不间断治疗胜过NSAIDs按需治疗（PICO1;非常低质量的证据; 90％表决同意）。 P8 We do not recommend any particular NSAID?as?the preferred choice (PICO 3; moderate- to lowquality evidence; conditional recommendation; vote 100% agreement). 我们不推荐任何特定的NSAID作为首选（PICO3;中度低质量的证据;有条件的建议; 100％表决同意）。 In adults with active?AS?despite treatment with NSAIDs, we conditionally recommend against treatment with SAARDs (PICO 7; very low- to moderate-quality evidence, depending on the drug; vote 90% agreement). 对于已使用过NSAIDs而病情依然活动的成人AS，我们建议（非绝对地）不要用SAARDs治疗（PICO 7;非常低到中等质量的证据（根据药物不同而异）; 90％表决同意）。 In adults with active?AS?despite treatment with NSAIDs: We strongly recommend treatment with TNFi over no treatment with TNFi (PICO 6; moderate-quality evidence; vote 80% agreement). 对于已使用过NSAIDs而病情依然活动的成人AS，我们强烈建议使用TNFi治疗胜于不使用TNFi治疗（PICO 6；中等质量的证据; 80％表决同意）。 We do not recommend any particular TNFi?as?the preferred choice, except for patients with concomitant inflammatory bowel disease or recurrent iritis (PICO 5; moderate-quality evidence; conditional recommendation; vote 100% agreement). 我们不推荐任何特定TNFi作为首选，除非患者同时合并有炎症性肠病或复发性虹膜炎（PICO 5;中等质量的证据;有条件的建议; 100％表决同意）。 In adults with active?AS?despite treatment with NSAIDs and who have contraindications to TNFi, we conditionally recommend treatment with a SAARD over treatment with a non-TNFi biologic agent (PICO 8; very low to lowquality evidence, depending on the drug; vote 100% agreement). 对于已使用过NSAIDs且对TNFi有禁忌、病情依然活动的成人AS，我们建议（非绝对地）使用一种SAARD治疗胜于使用一种非TNFi生物制剂治疗（PICO 8;非常低的