b6过脑胶质瘤BBB.pdf

Acta Biomaterialia 25 (2015) 172–183 Contents lists available at ScienceDirect Acta Biomaterialia journal homepage: www.elsevi /locate/actabiomat Sialic acid (SA)-modified selenium nanoparticles coated with a high blood–brain barrier permeability peptide-B6 peptide for potential use in Alzheimer’s disease Tiantian Yin, Licong Yang, Yanan Liu, Xianbo Zhou, Jing Sun, Jie Liu ⇑ Department of Chemistry, Jinan University, Guangzhou 510632, China a r t i c l e i n f o a b s t r a c t Article history: The blood–brain barrier (BBB) is a formidable gatekeeper toward exogenous substances, playing an Received 29 January 2015 important role in brain homeostasis and maintaining a healthy microenvironment for complex neuronal Received in revised form 17 June 2015 activities. However, it also greatly hinders drug permeability into the brain and limits the management of Accepted 30 June 2015 brain diseases. The development of new drugs that show improved transport across the BBB represents a Available online 2 July 2015 promising strategy for Alzheimer’s disease (AD) intervention. Whereas, previous study of receptor-mediated endogenous BBB transport systems has focused on a strategy of using transferrin to Keywords: facilitate brain drug delivery system, a system that still suffers from limitations including synthesis pro- Selenium nanopartic