Pyroptosis及炎性体活化的分子机制.pdf

314 ·综述· Pyroptosis及炎性体活化的分子机制 彭银高鸿方向明 cell death，PCD)模式。其 【摘要】背景Pyroptosis是一种依赖半胱天冬酶．1(caspase．1)的程序性细胞死亡(programmed 特征为快速的质膜破裂及炎性胞内容物的释放，最终诱发组织细胞呈现一种介于凋亡与坏死间的特殊程序性死亡—— pyroptosis。 是进化上保守的死亡模式，对机体炎性反应与免疫应答具有重要的调节作用。不同病原刺激细胞时，可引发胞浆内的多蛋白复 脓毒症、炎症性肠病等复杂免疫性疾病防治提供新的分子靶标。 【关键词】程序性细胞死亡；Pyroptosis；炎性体；半胱天冬酶．1 Molecularmechanismof andinflammasomeactivation 0 NG PENGYin’，GA pyroptosis Hong，FAXiang-ruing． First Medical 550004，China DepartmentofAnesthesiology，theAffiliozedHospitalofGuiyangCollege，Guiyang isa celldeath．Itfeatures 【Abstract】Backgroundeaspase1-dependentprogrammed rapid Pyroptosis andreleaseof intracellularcontentsandinducesa cell between rupture death，intermediate proinflammatory specialprogrammed and Thisarticlereviewsthemolecularmechanismof and necrosis，named apoptosis pyroptosis．Objective pyroptosis activationto the futureresearchandits ofclinical isaconservedcell explorepossible prospect application．ContentPyroptosis death inflammationandimmune stimulicould formationandactivationofa processmediating responses．Variouspathological trigger calledthe totheactivationof 1．Acombinationofdownstreamsuchaft muhiproteincomplex inflammasome，leadingcaspase processes of activated andDNA mediated plasma-membraneporeformation，release i