200808-Neurogenesis after primary intracerebral hemorrhage in adult(原发性脑出血后的神经再生).pdf

NIH Public Access Author Manuscript J Cereb Blood Flow Metab . Author manuscript; available in PMC 2008 October 29. N Published in final edited form as: I H J Cereb Blood Flow Metab . 2008 August ; 28(8): 1460–1468. doi:10.1038/jcbfm.2008.37. - P A A u Neurogenesis after primary intracerebral hemorrhage in adult t h o r human brain M a n 1 2 2 1 1 u Jianfeng Shen , Lin Xie , XiaoOu Mao , Yongqing Zhou , Renya Zhan , David A s 2 2 c Greenberg , and Kunlin Jin r i p 1 Department of Neurosurgery, First Affiliated Hospital, Zhejiang University College of Medicine, Zhejiang, t China 2 Buck Institute for Age Research, Novato, California, USA Abstract Neurogenesis occurs in discrete regions of normal brains of adult mammals including humans, and N is induced in response to brain injury and neurodegenerative disease. Whether intracerebral I H hemorrhage can also induce neurogenesis in human brain is unknown. Specimens were obtained - P from patients with primary intracerebral hemorrhage undergoing surgical evacuation of an A intracerebral hematoma, and evaluated by two-photon laser scanning confocal microscopy. We found A u that neural stem/progenitor cell-specific protein markers were expressed in cells located in the t h perihematomal regions of the basal ganglia and parietal lobe of the adult human brain after primary o r intracerebral hemorrhage (n = 5). Cells in this region also expres