危重病患者降钙素原和白细胞介素-6表达及易感性研究.docVIP

精品论文 参考文献 危重病患者降钙素原和白细胞介素-6表达及易感性研究 徐盈 钟玲 高琴芬 （云南省第一人民医院昆明医科大学附属昆华医院EICU 650032） 【摘要】目的 探讨细胞因子在全身炎症反应综合征（SIRS）向多器官功能障碍综合征（MODS）进展中的诊断价值和临床意义。方法 用放射免疫荧光法测定SIRS组、正常对照组、动态观察组血清降钙素原（PCT）、白细胞介素-6（IL-6）含量。结果 血清PCT、IL-6 的含量于危重病患者发病后24h内即明显高于正常对照组（Plt;0.01）；动态观察组中两项指标含量呈先升后下降趋势，高峰值出现在第6天，同时各时间段测值仍显著高于正常对照组（Plt;0.01）。结论 危重患者SIRS发生后24h内PCT与IL-6等炎性因子参与了SIRS向MODS发生发展过程；SISR患者早期血清PCT、IL-6测定可作为并发MODS的评估指标。 【关键词】 全身炎症反应综合症 多器官功能衰竭 PCT IL-6 【中图分类号】R39 【文献标识码】A 【文章编号】2095-1752（2013）26-0065-03 Clinical value of PCT and IL-6 in the critical patients Xu Ying, Zhong Ling， Gao Qingfen, Department of emergency ICU, The first peoplersquo;s hospital of Yunnan province, Kunming 650032 【Abstract】 Objective To explore the diagnostic value and clinical significance of cytokines in the progress from systemic inflammatory response syndrome (SIRS) to multiple organ dysfunction syndrome (MODS). Methods Serum procalcitonin (PCT) and interleukin -6 (IL-6) were measured with immunofluorescence in SIRS group and healthy control group. Results The content of serum PCT) and IL-6 in critical patients after 24h were significantly higher than normal control group (P lt;0.01). The two indexes were first increased and then declined. Peak value occurred in the sixth day, meanwhile the values were significantly higher than the normal control group in different time(P lt;0.01). Conclusion The inflammatory factors such as PCT and IL-6 involved in the progress from SIRS to MODS in the critical patients with SIRS after 24h. Serum PCT and IL-6 can be used as an evaluation index of MODS in patients with SISR. 【KEY WORDS】 systemic inflammatory response syndrome multiple organ dysfunction syndrome procalcitonin interleukin -6 (IL-6) 多器官功能障碍综合征（multiple organ dysfunctional syndrome，MODS）是严重创伤、烧伤、重症胰腺炎、心肺脑复苏等非感染性疾病及脓毒症等感染性疾病共同存在的难点问题。近年来，尽管现代医疗技术和重症监护水平明显提高，但危重患者的死亡率仍高达70%左右，多数患者死于进行性多器官功能紊乱综合征（MODS），而全身炎症反应综合征（systemic inflammatory respo