原发性食管小细胞癌临床病理组织学及免疫组化分析.docVIP

精品论文 参考文献 原发性食管小细胞癌临床病理组织学及免疫组化分析 田晓爱 　　（山西省汾阳医院病理科 山西 汾阳 032200） 　　【摘要】目的：通过对32例原发性食管小细胞癌临床、病理组织学及免疫组化的分析，总结食管小细胞癌临床、病理特征及免疫组化特点。方法：对32例原发性食管小细胞癌临床、病理及免疫组化结果，采用回顾性分析方法，进行归纳总结。结果：食管小细胞癌分为单纯小细胞型、混合细胞型两种类型，镜下多为单纯小细胞型。免疫组化示肿瘤细胞表达NSE（神经元特异烯醇化酶）、Syn(突触素)、CgA(嗜铬蛋白A)，阳性表达率NSE为91.3%，Syn为94.3%，CgA为80.1%。结论：原发性食管小细胞癌有其独特的临床、病理特点及免疫组化特点，确诊主要依据病理组织学及免疫组化检查。 　　【关键词】原发性食管小细胞癌；病理组织学；免疫组化 　　【中图分类号】R730. 2 【文献标识码】A 【文章编号】2095-1752（2015）05-0016-02 　　Primary esophageal small cell carcinoma clinical pathological histology and immunohistochemical analysis Tian Xiaoai. Fenyang Hospital, Shanxi Province, Fenyang 032200, China 　　【Abstract】Objective In 32 cases of primary esophageal small cell carcinoma of the clinical, pathological histology and immunohistochemical analysis, summary of esophageal small cell carcinoma of the clinical, pathological features and immunohistochemical characteristics. Methods 32 cases of primary esophageal small cell carcinoma clinical, pathologic and immunohistochemical results, using retrospective analysis method, were summarized. Results Small cell carcinoma of the esophagus is divided into simple small cell type, mixed cell type two kinds, mirror for more simple small cell type. Immunohistochemical expression of NSE of tumor cells (neurons specific enolization enzyme), Syn (synapses), CgA chromaffin protein (A), NSE positive expression rate is 91.3%, Syn was 94.3%, the CgA is 80.1%. Conclusions Primary esophageal small cell carcinoma has its unique clinical, pathological features and immunohistochemical features, diagnosis is mainly based on pathological histology and immunohistochemical examination. 　　【Key words】Primary small cell carcinoma of the esophagus; The pathological histology; Immunohistochemical 　　原发性食管小细胞癌（primary esophageal small cell carcinoma,PESC）是食管少见恶性肿瘤，其发病率占食管恶性肿瘤的1%～1.5%[1]。其恶性程度高，局部复发及远处转移率高，生存时间短。其组织形态和生物学行为有别于食管鳞癌及腺癌，而类似肺小细胞未分化癌[2]。食管镜活检对此病的诊断有一定的局限性[3]。 2009年1月至2014年10月我科手术治疗32例PESC，本文对32例PESC的临床、病理组织学及免疫