The Cell-Derived Mediators of Chemical Mediators of Inflammation细胞产生的炎症化学介质，介质.pptVIP

下载本文档

5
0
约9.28千字
约 36页
2017-12-23 发布于江西
举报
版权申诉

The Cell-Derived Mediators of Chemical Mediators of Inflammation细胞产生的炎症化学介质，介质.ppt

1、本文档共36页，可阅读全部内容。
2、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

The Cell-Derived Mediators of Chemical Mediators of Inflammation细胞产生的炎症化学介质，介质

The Cell-Derived Mediators of Chemical Mediators of Inflammation Presented by Sara M. Al-Shaker Wed. 5/11/2008 King Saud University Riyadh, KSA Introduction What are mediators? A mediator is a substance or structure that mediates a specific response in a bodily tissue General Properties of Chemical Mediators of Inflammation Site of production Local or remote Method of action Mostly by binding to receptors May have direct enzymatic and/or toxic effects General Properties of Chemical Mediators of Inflammation Some mediators Stimulate release of secondary effector molecules Actions of most mediators are tightly regulated Decay Enzymatic inactivation Elimination Inhibition Cell-Derived Mediators Producing cells: Tissue macrophages Mast cells Endothelial cells Leukocytes Vasoactive Amines Histamine Serotonin Vasoactive Amines Among first mediators in acute inflammatory reactions Preformed mediators in secretory granules Histamine Source: many cell types, esp. mast cells, circulating basophils, and platelets Actions: ARTERIOLAR DILATION INCREASED VASCULAR PERMEABILITY ENDOTHELIAL ACTIVATION Inactivated by: Histaminase Histamine Stimuli of Release: Physical injury Immune reactions C3a and C5a fragments of complement (anaphylatoxins) Leukocyte-derived histamine-releasing proteins Neuropeptides (e.g. substance P) Certain Cytokines (e.g. IL-1 and IL-8) Serotonin(5-HT) Source: Platelets Action: Similar to histamine’s Stimulus: Platelet aggregation Eicosanoids Eicosanoids = Arachidonic Acid (AA) Metabolites = Prostaglandins (PG), Leukotrienes, and Lipoxins Eicosanoids May be thought of as hormones but they differ from hormones by: Produced in all tissues rather than in specialized glands Act locally rather than after transport in blood to distant sites Decay spontaneously OR enzymatically Have short half-life Eicosanoids Source: Leukocytes Mast cells Endothelial cells Platelets Arachidonic Acid 20-carbon polyunsaturated fatty acid (4 double bonds) Obtai