THE GENETIC OF CANCER：癌症的遗传.ppt

THE GENETIC OF CANCER ROLES OF CANCER GENES IN CELL SIGNALING PROTO-ONCOGENES AND ONCOGENES TUMOR SUPPRESSOR GENES EFFECT OF CANCER GENES ON CELL CYCLE COMMON FORMS OF CANCER TREATMENT THERAPEUTIC TARGETS AGAINST CANCER CELLS IMMUNOTHERAPY AGAINST CANCER CELLS MONOCLONAL ANTIBODIES AS RADIATION AND DRUG CARRIERS GENE THERAPY OF CANCER * Increased mitosis Tumor formation Tumor suppression gene Hyperactive growth Translocation Point mutation Amplification Normal growth Normal growth Proto-oncogene Normal protein Defective protein Normal cell division Uncontrolled cell division Excessive protein stimulation Proto-oncogenes code for growth factors Mutations cause overproduction of growth factors Proto-oncogenes code for growth factor receptors Mutant receptor no longer requires growth factor binding Proto-oncogenes code for transcription factors Factors always bind to their target gene promotor Proto-oncogenes code for proteins that transmit external stimuli for cell division. Stimulation no longer needed Oncogenes Tumor suppressor genes Chemotherapy Radiotherapy Surgery May be used alone or in combination Inactivation cell surface receptor Inhibition of angiogenesis Inhibition of metastasis Inactivation of receptor-associated G-proteins Inhibition of amplifying enzymes Inhibition of Rb protein Inhibition of p53 protein Tumor cell with target antigen Antibodies against target antigen Binding to target receptor Complement activation Destruction by cytotoxic T cells Monoclonal Antibodies as radiation carrier Monoclonal Antibodies as drug carrier Chemotherapeutic agent Radioactive label *