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麻省理工学院 生物材料课程 lecture 18 Drug Delivery Controlled Release Chemically-controlled Devices
Lecture 18:
Drug Delivery: Controlled Release
Chemically-controlled Devices
3.051J/20.340J Materials for Biomedical Applications,
Spring 2006
1
Drug Delivery System (DDS)
Controlling delivery rate and Site-specific delivery of drugs
Current drug administration
Toxic level
Drug conc. Controlled (or Sustained) Release
Minimum effective level
Time
2
Even though controlled release can be achieved…
Spread over body Site-specific delivery
Active or passive
targeting
might cause side effect.
3
Table Controlled Release DDS
Diffusion-controlled DDS
Reservoir and monolithic systems
Water penetration-controlled DDS
Osmotic and swelling-controlled systems
Chemically-controlled DDS
Biodegradable reservoir and monolithic systems
Biodegradable polymer backbones with pendant drugs
Responsive DDS
Physically- and chemically-responsive systems
Mechanical, magnetic- or ultrasound-responsive systems
Biochemically-responsive; self-regulated systems
Particulate DDS
Microparticulates
Polymer-drug conjugates
Polymeric micelle systems Ratner, et al. Biomaterials Science
Liposome systems 4
Chemically-controlled DDS
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