有哪些信誉好的足球投注网站- 1、本文档共16页，可阅读全部内容。
- 2、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
- 3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
查看更多
麻省理工学院 生物材料课程 Lecture 9 Surface Modification of Biomaterials Supporting notes
Lecture 9:
Surface Modification of Biomaterials
Supporting notes
3.051J/20.340J Materials for Biomedical Applications,
Spring 2006
1
Purpose:
Alter surface properties to enhance performance in
biological environment while retaining bulk properties
of device
The modified zone at the surface of the device should be
as thin as possible. Ideally 1 nm
2
Specific objectives:
1. Clean a surface
2. Reduce/eliminate protein adsorption
3. Reduce/eliminate cell adhesion
4. Reduce bacterial adhesion
5. Reduce thrombogenicity
6. Promote cell attachment/adhesion
7. Alter transport properties
8. Increase lubricity
9. Increase hardness
10.Enhance corrosion/degradation resistance
3
Preparation of non-fouling surfaces
to prevent non-specific protein/cell or bacterial adhesion
to reduce thrombogenicity
Figure by MIT OCW.
Surfaces should be hydrophilic or very hydrophobic.
4
Example of “gold standard”
Surface modification with PEO derivative.
PEO-PPO-PEO, Pluronic
Physical adsorption Chemical immobilization
Short-time use Long-time use
Ex. Drug delivery
5
Other strategies for hydrophilic surfaces 1
Albumin coating surface Phospholipid-mimicking surface
N+ N+ N+ N+
文档评论（0）